caa a22 4500 469094028 CHVBK 20180323133025.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576290 doi (NATIONALLICENCE)springer-10.1007/BF02576290 Cardiac glycosides in the treatment of experimental overdose with calcium-blocking agents [Elektronische Daten] [M. Ramo, I. Grupp, M. Pesola, J. Heikkila, K. Luomanmaki, T. Schroder, G. Grupp] Summary: The ability of digitalis compounds to counteract calcium antagonist overdose was studied in anesthetized dogs (n=6, 13.5±0.7 kg) and isolated trabeculae from human hearts (n=7). Digitalis caused by increasing intracellular cytosolic Ca2+ concentration through Na+/Ca2+-exchange across the cell membrane, was postulated to overcome the detrimental effects of excessive slow calcium-channel blockade. In anesthetized dogs, an infusion of verapamil (40 mg/30 min, i.v.) decreased mean arterial pressure from 88±6 to 66±6 mm Hg (P<0.05), reduced systemic vascular resistance (SVR) from 3838±916 to 2200±669 dyne·s/cm5 (P<0.05), and induced total atrio-ventricular (A-V) block in three animals. Stroke volume (SV) remained unchanged. Administration (i.v.) of NaCl (0.9%, 200 ml) and calcium gluconate (100 mg)—to increase the availability of Na+ and Ca2+—together with atropine (0.2 mg)—to block the parasympathetic effects of digoxin on A-V conduction—increased left ventricular contractility (15%) but had no significant effects on blood pressure, SV, or A-V block. Digoxin (0.125 mg) returned sinus rhythm in all dogs and, by increasing SVR (P<0.05) and left ventricular contractility (P<0.05), returned arterial pressures to baseline. Because of increased afterload, SV decreased slightly (15%) despite increased cardiac contractility. In experiments with isolated trabeculae from diseased human hearts TA 3090 (Clentiazem) depressed contractile force and ouabain, another glycoside, restored contractile force within 30 min. Ouabain also counteracted the depression produced by anipamil, nifedipine, and amlodipine. In conclusion, these experimental results indicate that administration of digoxin, combined with atropine, may be beneficial in the treatment of verapamil overdose. Springer-Verlag, 1992 Ca2+ antagonists nationallicence Poisoning nationallicence Cardiac glycosides nationallicence Atropine nationallicence Ramo M. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut Grupp I. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut Pesola M. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut Heikkila J. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut Luomanmaki K. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut Schroder T. Department of Surgery, University of Oulu, Department of Surgery, University of Helsinki, Finland aut Grupp G. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 335-343 0300-9130 192:1<335 1992 192 433 https://doi.org/10.1007/BF02576290 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576290 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramo M. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut NATIONALLICENCE 700 1- Grupp I. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut NATIONALLICENCE 700 1- Pesola M. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut NATIONALLICENCE 700 1- Heikkila J. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut NATIONALLICENCE 700 1- Luomanmaki K. Department of Physiology, University of Oulu, Department of Internal Medicine, University of Helsinki, Finland aut NATIONALLICENCE 700 1- Schroder T. Department of Surgery, University of Oulu, Department of Surgery, University of Helsinki, Finland aut NATIONALLICENCE 700 1- Grupp G. Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, USA aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 335-343 0300-9130 192:1<335 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer