caa a22 4500 469094044 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576264 doi (NATIONALLICENCE)springer-10.1007/BF02576264 Effect of sulfasalazine on adaptive and functional changes in intestine of normal and protein-calorie-malnourished rats [Elektronische Daten] [S. Chadha, U. Kanwar, S. Sanyal] Summary: The effects of sulfasalazine (500 mg/kg body weight daily for 35 days) and its subsequent recovery for another 35 and 65 days have been investigated on the intestinal uptake of certain end-product nutrients, viz. glucose, leucine, alanine, and calcium, in normal and protein-calorie malnourished (PCM) male albino rats. Sulfasalazine administration caused a reduction in body weight in PCM animals, while intestinal weight and length as well as protein and nucleic-acid contents were reduced in both normal and PCM animals. Serum proteins also showed a decrease in PCM rats. PCM rats showed elevated levels of glucose, amino acids, and calcium uptake by the intestinal segments, but sulfasalazine feeding inhibited the uptake of nutrients both in normal-fed and malnourished animals. All these changes were found to be reversible after the withdrawal of drug treatment. Sulfasalazine caused a decrease in the Na+-dependent (active) glucose uptake as well as the Na+-independent (passive) process. The kinetic parameters of glucose uptake indicate that the drug might interfere with the transport/carrier protein of these nutrients, because reduction was observed in maximum uptake velocity (Jmax) of these systems without any change in the affinity constant (Kt). Springer-Verlag, 1992 Sulfasalazine nationallicence Intestinal absorption nationallicence Glucose nationallicence Amino acid nationallicence Na+-coupled transport nationallicence Protein-calorie malnutrition nationallicence Chadha S. Department of Zoology, Panjab University, 160014, Chandigarh, India aut Kanwar U. Department of Zoology, Panjab University, 160014, Chandigarh, India aut Sanyal S. Department of Biophysics, Panjab University, 160014, Chandigarh, India aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 105-113 0300-9130 192:1<105 1992 192 433 https://doi.org/10.1007/BF02576264 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576264 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chadha S. Department of Zoology, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 700 1- Kanwar U. Department of Zoology, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 700 1- Sanyal S. Department of Biophysics, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 105-113 0300-9130 192:1<105 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer