caa a22 4500 469094141 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576283 doi (NATIONALLICENCE)springer-10.1007/BF02576283 Hemodynamic effects following intraperitoneal infusion of pancreatic ascites fluid [Elektronische Daten] [B. Vollmar, H. Waldner, M. Vierl, T. Kerner, P. Lehnert, L. Schweiberer] Summary: Severe necrotizing pancreatitis is accompanied by release of hemorhagic ascites fluid (HAF), which is thought to be related to the occurrence and frequency of cardiocirculatory and pulmonary failure as a consequence of acute pancreatitis. The purpose of this study was to evaluate the role of HAF due to these systemic complications. Experiments were performed in 25 pigs (mean b.wt. 22±1kg) under general anesthesia and mechanical ventilation. The animals received 50 ml/kg b.wt. i.p. of either physiologic saline solution (control CO,n=9) or hemorrhagic ascites fluid (HAF,n=16). HAF was obtained from 16 pigs with pancreatitis induced by intraductal infusion of bile salt. Eight animals in the HAF group were pretreated with indomethacin (10 mg/kg i.v. INDO/HAF). All animals were followed up for 6h. Mean arterial pressure, cardiac output, and stroke volume fell significantly in the HAF(−25%, −27%, −27%) and in the INDO/HAF groups (−24%, −20%, −17%) as compared with controls (−6%, −6%, −6%). Also, left ventricular end-diastolic pressure (LVEDP) decreased by 52% and 48% in both HAF recipient groups, whereas LVEDP was unchanged in the control group. Myocardial contractility (Vmax) remained unaltered in all experimental groups. No significant differences in gas exchange and lung dry/wet weight ratio were observed. Lipase and PGI2 of the unpretreated HAF group rised to 203% and 198% in arterial blood at 6h compared with unaltered levels in the control group. No increase of prostanoid concentrations was detected in the indomethacin-pretreated group, whereas lipase increase by a comparable extent as in the HAF group. We conclude that the early consequences of HAF are mainly characterized by systemic hypotension due to hypovolemia. Springer-Verlag, 1992 Pancreatic ascites fluid nationallicence Hemodynamics nationallicence Hypovolemia nationallicence Peritoneal lavage nationallicence Vollmar B. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Waldner H. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Vierl M. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Kerner T. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Lehnert P. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Schweiberer L. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 269-279 0300-9130 192:1<269 1992 192 433 https://doi.org/10.1007/BF02576283 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576283 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vollmar B. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 700 1- Waldner H. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 700 1- Vierl M. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 700 1- Kerner T. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 700 1- Lehnert P. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 700 1- Schweiberer L. Institute of Surgical Research and the Department of Surgery, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Marchioninistrasse 15, W-8000, München 70 aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 269-279 0300-9130 192:1<269 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer