caa a22 4500 46909415X CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576271 doi (NATIONALLICENCE)springer-10.1007/BF02576271 Conversion of mitochondrial redox state toward oxidation by prostacyclin in 70%-hepatectomized rats [Elektronische Daten] [Taisuke Morimoto, Kazue Ozawa, Wolf Isselhard] Summary: Arterial blood ketone body ratio (KBR) and hepatic mitochondrial phosphorylation rate (PR) were investigated in partially (70%) hepatectomized rats treated with 100 μg/kg body weight prostacyclin (PGI2) analogue i.p. after operation and every 12 h thereafter up to 72h. Sampling was performed at 12, 24, 48, and 72 h after operation. In sham-operated rats, KBR significantly increased from the preoperative values of 0.34±0.03 and 0.38±0.03, to 0.55±0.03 and 0.58±0.02 at 12 h in the groups with and without PGI2 treatment, respectively (P<0.001). KBR returned to the preoperative levels after 24 h in the PGI2-treated group, while it tended to be in the lower normal range in the untreated group. In the hepatectomized rats, KBR significantly decreased in the untreated group compared with the preoperative values and the values in the sham-operated group. It returned to the preoperative range within 72h. In the PGI2-treated group, KBR increased significantly, to values above 0.54, after a 24-h delay and was maintained at those levels for 72h. Concentrations of total ketone bodies (TKB) in the untreated groups remained in the upper range of preoperative values (above 200 nmol/ml) in the sham-operated rats and decreased significantly in the hepatectomized group (234 to 126 nmol/ml). TKB in the treated groups tended to decrease only in the sham-operated group (205 to 166 nmol/ml), and was massively reduced in the hepatectomized group (167 to 81 nmol/ml). PR was significantly enhanced after hepatectomy until 48h both in the groups with and without PGI2 treatment, but the degree of enhancement in PR was lower in the group with treatment than the one without treatment during the period of mitochondrial enhancement. It is suggested that PGI2 may convert the mitochondrial redox state toward oxidation accompanied by a suppression of ketogenesis and may activate the tricarboxylic acid (TCA) cycle. It is also suggested that PGI2 treatment may make it less necessary for mitochondria in the remnant liver to be enhanced to compensate the metabolic overload on the remnant liver and that PGI2 treatment may have a promoting effect on liver regeneration after hepatectomy. Springer-Verlag, 1992 Partial hepatectomy nationallicence Mitochondrial redox state nationallicence Arterial blood ketone body ratio nationallicence Mitochondrial enhancement nationallicence Prostacyclin nationallicence Morimoto Taisuke Second Department of Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, 606, Kyoto, Japan aut Ozawa Kazue Second Department of Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, 606, Kyoto, Japan aut Isselhard Wolf Institute of Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, W-5000, Köln 41, Federal Republic of Germany aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 161-168 0300-9130 192:1<161 1992 192 433 https://doi.org/10.1007/BF02576271 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576271 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morimoto Taisuke Second Department of Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Ozawa Kazue Second Department of Surgery, Faculty of Medicine, Kyoto University, Sakyo-ku, 606, Kyoto, Japan aut NATIONALLICENCE 700 1- Isselhard Wolf Institute of Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, W-5000, Köln 41, Federal Republic of Germany aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 161-168 0300-9130 192:1<161 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer