caa a22 4500 469094176 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576267 doi (NATIONALLICENCE)springer-10.1007/BF02576267 Liver regeneration following portacaval shunt in rats: 3′, 5′-cyclic AMP changes in plasma and liver tissue [Elektronische Daten] [Y. Hata, Y. Yoshikawa, Y. Une, F. Sasaki, Y. Nakajima, H. Takahashi, T. Namieno, J. Uchino] Summary: Hepatic regeneration following portacaval shunt was evaluated in the light of the changes of 3′, 5′-cyclic AMP (cAMP) levels in plasma and liver tissue, and also plasma cAMP levels after glucagon administration, using a 70% hepatectomy and portacaval shunt model in rats. Ratios of liver to body weight recovered to 60% of pre-operative ratios 2 weeks after the operation. Plasma cAMP level decreased slightly, but insignificantly, 1 day and 3 days after the operation, then recovered to the pre-operative level. Hepatic cAMP concentration increased for 2 weeks after the operation. Plasma cAMP levels induced after glucagon administration did not increase until 3 days after the operation and were only 50% of pre-operative levels 4 weeks after the operation. From these results, liver regeneration following the portacaval shunt was remarkably delayed, but continued until at least 2 weeks after the operation. Springer-Verlag, 1992 Liver regeneration nationallicence Portacaval shunt nationallicence 3′, 5′-cyclic AMP nationallicence Hata Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Yoshikawa Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Une Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Sasaki F. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Nakajima Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Takahashi H. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Namieno T. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Uchino J. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 131-136 0300-9130 192:1<131 1992 192 433 https://doi.org/10.1007/BF02576267 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576267 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hata Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Yoshikawa Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Une Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Sasaki F. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Nakajima Y. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Takahashi H. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Namieno T. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 700 1- Uchino J. First Department of Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-ku, 060, Sapporo, Japan aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 131-136 0300-9130 192:1<131 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer