caa a22 4500 469094206 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576278 doi (NATIONALLICENCE)springer-10.1007/BF02576278 Age-related alterations in second-messenger systems in the gerbil brain: autoradiographic analysis and effect of vinconate [Elektronische Daten] [Tsutomu Araki, Yasuo Kanai, Hiroyuki Kato, Kyuya Kogure, Yukiharu Ishida] Summary: Age-related alterations in binding sites of major second-messenger systems in the gerbil brain were analyzed by receptor autoradiography using [3H]phorbol 12, 13-dibutyrate (PDBu), and [3H]inositol 1,4,5-trisphosphate (IP3). In middle-aged gerbils (16 months old), the reduction of PDBu-binding sites was noticed in various brain regions compared with young animals (4 weeks old). By contrast, the elevation of IP3-binding sites was seen in most of brain regions except for the reduction in the cerebellum in the middle-aged animals. Chronic treatment with vinconate partly regulated the age-related changes in the binding sites of these second messengers. The result demonstrates the age-related alterations in the binding sites of an intracellular second-messenger system. Furthermore, they suggest that vinconate partly modulates the age-related alterations in the bindings of second messengers. Springer-Verlag, 1992 Aging nationallicence Second messengers nationallicence Receptor nationallicence Vinconate nationallicence Gerbil nationallicence Araki Tsutomu Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut Kanai Yasuo Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe, 115, Tokyo, Japan aut Kato Hiroyuki Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut Kogure Kyuya Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut Ishida Yukiharu Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe, 115, Tokyo, Japan aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 221-230 0300-9130 192:1<221 1992 192 433 https://doi.org/10.1007/BF02576278 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576278 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Araki Tsutomu Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Kanai Yasuo Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe, 115, Tokyo, Japan aut NATIONALLICENCE 700 1- Kato Hiroyuki Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Kogure Kyuya Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Ishida Yukiharu Pharmacological Research Laboratory, Research Laboratories, Tokyo Tanabe, 115, Tokyo, Japan aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 221-230 0300-9130 192:1<221 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer