caa a22 4500 469094214 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576255 doi (NATIONALLICENCE)springer-10.1007/BF02576255 Recovery of hepatic clearance and extraction following a release of common bile duct obstruction in the rat [Elektronische Daten] [E. Melzer, Z. Krepel, I. Ronen, S. Bar-Meir] Summary: The rat of recovery for hepatic clerance and extraction following release of common-duct obstruction was investigated in the rat. Male Wistar rats underwent ligation of a cannulated common bile duct. Two weeks later, the cannula was opened and implanted into the duodenum, thus re-establishing enterohepatic circulation. Hepatic extraction and indocyanine green clearance were determined in three groups of six rats each, which differed by the time elapsed from the re-establishment of communication between the common bile duct and duodenum, i.e., 1, 48 and 168 h, respectively. A fourth group, in which a sham operation was performed, served as a control. Clearance was reduced from 16.9±2.5 ml/min per kg in the control group to 2.9±0.8, 5.4±2.4, and 8.5±3.3 ml/min per kg 1, 48, and 168 h, respectively, after release of common-bile-duct obstruction. Extraction rate was reduced from 37.3±5.9% to 17.5±2.7% in the 1st hour and recovered completely at 1 week. Thus, in the rat, release of a 2-week common-bile-duct obstruction is associated with complete recovery of the extraction capacity of the liver within a week, but only incomplete recovery of clearance. This decrease in clearance seems to be due to a decrease in effective hepatic blood flow, mostly probably due to the development of porto-systemic shunts. Springer-Verlag, 1992 Liver recovery nationallicence Common-bile-duct obstruction nationallicence Hepatic extraction nationallicence Hepatic clearance nationallicence Melzer E. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut Krepel Z. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut Ronen I. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut Bar-Meir S. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 35-40 0300-9130 192:1<35 1992 192 433 https://doi.org/10.1007/BF02576255 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576255 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Melzer E. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Krepel Z. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Ronen I. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Bar-Meir S. Department of Gastroenterology, Edith Wolfson Hospital, Holon, and Sackler School of Medicine, Tel-Aviv, Israel aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 35-40 0300-9130 192:1<35 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer