caa a22 4500 469094222 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02576263 doi (NATIONALLICENCE)springer-10.1007/BF02576263 Coumarins: macrophage proteinase production and pinocytosis [Elektronische Daten] [K. Knight, G. Vairo, J. Hamilton, D. Lepore] Summary: Coumarins, which are thought to stimulate macrophage proteinase activity, have been advocated for the treatment of high protein oedemas, such as obstructive lymphoedema. In experiments with cultured murine macrophages, coumarin and 7-hydroxycoumarin (10−3 or 10−4 M) had no significant effect on plasminogen-activator activity, plasminogen-independent fibrinolytic activity or pinocytosis. Although no in vitro effect on macrophage proteinase activity was found, it is possible that coumarins acitvate other cell types in vivo and thus effectively treat lymphoedema. Springer-Verlag, 1992 Coumarin and derivatives nationallicence Macrophages nationallicence Plasminogen activator nationallicence Pinocytosis nationallicence Lymphoedema nationallicence Knight K. Microsurgery Research Centre, St. Vincent's Hospital, 3065, Melbourne, Australia aut Vairo G. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 3050, Parkville, Australia aut Hamilton J. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 3050, Parkville, Australia aut Lepore D. Microsurgery Research Centre, St. Vincent's Hospital, 3065, Melbourne, Australia aut Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 99-103 0300-9130 192:1<99 1992 192 433 https://doi.org/10.1007/BF02576263 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02576263 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knight K. Microsurgery Research Centre, St. Vincent's Hospital, 3065, Melbourne, Australia aut NATIONALLICENCE 700 1- Vairo G. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 3050, Parkville, Australia aut NATIONALLICENCE 700 1- Hamilton J. Department of Medicine, Royal Melbourne Hospital, University of Melbourne, 3050, Parkville, Australia aut NATIONALLICENCE 700 1- Lepore D. Microsurgery Research Centre, St. Vincent's Hospital, 3065, Melbourne, Australia aut NATIONALLICENCE 773 0- Research in Experimental Medicine Springer-Verlag 192/1(1992-12-01), 99-103 0300-9130 192:1<99 1992 192 433 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer