caa a22 4500 469094281 CHVBK 20180323133026.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00243093 doi (NATIONALLICENCE)springer-10.1007/BF00243093 Growth plate injury of the long bones in treated β-thalassemia [Elektronische Daten] [Carlo Orzincolo, Pier Scutellari, Giuseppe Castaldi] In 12 patients affected by thalassemia major who received an intensive transfusion regimen combined with continuous iron chelation therapy (desferrioxamine 50-80 mg/kg daily), radiologic abnormalities of the long bones were observed similar to those observed in rickets and scurvy. These abnormalities were associated with a growth retardation. The pathogenesis of these lesions is uncertain, but probably the toxic effect of desferrioxamine plays an important role in their development. A relative deficiency of vitamins D and/or C cannot be entirely excluded. International Skeletal Society, 1992 β-Thalassemia nationallicence Desferrioxamine nationallicence Growth plate injury nationallicence Orzincolo Carlo Department of Radiology, St. Anna Hospital, Ferrara aut Scutellari Pier Institute of Radiology, Ferrara University School of Medicine, Italy aut Castaldi Giuseppe Department of Medicine, St. Maria delle Croci Hospital, Ravenna, Italy aut Skeletal Radiology Springer-Verlag 21/1(1992-01-01), 39-44 0364-2348 21:1<39 1992 21 256 https://doi.org/10.1007/BF00243093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00243093 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Orzincolo Carlo Department of Radiology, St. Anna Hospital, Ferrara aut NATIONALLICENCE 700 1- Scutellari Pier Institute of Radiology, Ferrara University School of Medicine, Italy aut NATIONALLICENCE 700 1- Castaldi Giuseppe Department of Medicine, St. Maria delle Croci Hospital, Ravenna, Italy aut NATIONALLICENCE 773 0- Skeletal Radiology Springer-Verlag 21/1(1992-01-01), 39-44 0364-2348 21:1<39 1992 21 256 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer