caa a22 4500 469094761 CHVBK 20180323133027.0 cr unu---uuuuu 170328e19921001xx s 000 0 eng 10.1007/BF00190990 doi (NATIONALLICENCE)springer-10.1007/BF00190990 Magnetic resonance imaging of Achilles tendon xanthomas in familial hypercholesterolemia [Elektronische Daten] [Mike Liem, Jan Leuven, Johan Bloem, Jaap Schipper] The demonstration of tendon xanthomas is helpful in diagnosing heterozygous familial hypercholesterolemia, but in many patients lipid may accumulate without clinical abnormality being present. We investigated the possibility of detecting the lipid element with magnetic resonance (MR) imaging in seven patients with familial hypercholesterolemia and six controls. Although the mean relative signal intensities measured on long TR/TE spin echo sequences of the tendon were signifycantly higher in patients than in controls, the lack of such elevation does not rule out the presence of such lesions. In vitro measurements indicated that the signal intensity of triglycerides was quenched by cholesterolesters. The anatomic findings of MR imaging were compared with those of ultrasonography (US), showing excellent correlation in measurements between MR images and US [r(S) = 0.95 and 0.97 respectively] MR imaging and US provide equal information on the anatomy of the Achilles tendon; as an abnormally increased signal intensity within the xanthoma on MRI was found in only a minority of our patients, the value of MRI in the demonstration of Achilles tendon xanthomas is limited when using conventional T1 and T2 spin echo sequences. International Skeletal Society, 1992 Magnetic resonance imaging nationallicence Tendon xanthoma nationallicence Familial hypercholesterolemia nationallicence Ultrasonography nationallicence Liem Mike Department of Radiology, University Hospital Leiden, The Netherlands aut Leuven Jan IVVO-TNO, Gaubius Laboratory, Leiden, The Netherlands aut Bloem Johan Department of Radiology, University Hospital Leiden, The Netherlands aut Schipper Jaap Department of Radiology, University Hospital Leiden, The Netherlands aut Skeletal Radiology Springer-Verlag 21/7(1992-10-01), 453-457 0364-2348 21:7<453 1992 21 256 https://doi.org/10.1007/BF00190990 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00190990 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liem Mike Department of Radiology, University Hospital Leiden, The Netherlands aut NATIONALLICENCE 700 1- Leuven Jan IVVO-TNO, Gaubius Laboratory, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Bloem Johan Department of Radiology, University Hospital Leiden, The Netherlands aut NATIONALLICENCE 700 1- Schipper Jaap Department of Radiology, University Hospital Leiden, The Netherlands aut NATIONALLICENCE 773 0- Skeletal Radiology Springer-Verlag 21/7(1992-10-01), 453-457 0364-2348 21:7<453 1992 21 256 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer