caa a22 4500 469104406 CHVBK 20180323133053.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00770608 doi (NATIONALLICENCE)springer-10.1007/BF00770608 Successes and perspectives in the creation of therapeutic preparations based on ascorbic acid (review) [Elektronische Daten] [É. Parfenov, L. Smirnov] Conclusions: Thus, increases in therapeutic effects can be achieved by various methods: by increasing ascorbic acid doses, by combing ascorbic acid with synergistic agents, and by using it as a chemoprotector against xenobiotics; the most effective way is by chemical modification. Increasing lipophilicity can widen the spectrum of biological activity in the desired direction, and substitution of the hydroxyl group or the carbon at position 2 prolongs the antioxidant activity of ascorbic acid and its associated pharmacological effects, as does complex formation (when the chemical structure of ascorbic acid is not changed), which increases the antioxidant activity — the most important prerequisite for its biological Plenum Publishing Corporation, 1993 Parfenov É. All-Union Scientific Center for the Safety of Biologically Active Substances, Kupavna aut Smirnov L. All-Union Scientific Center for the Safety of Biologically Active Substances, Kupavna aut Pharmaceutical Chemistry Journal Kluwer Academic Publishers-Plenum Publishers 26/9-10(1992-09-01), 657-676 0091-150X 26:9-10<657 1992 26 11094 https://doi.org/10.1007/BF00770608 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00770608 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parfenov É. All-Union Scientific Center for the Safety of Biologically Active Substances, Kupavna aut NATIONALLICENCE 700 1- Smirnov L. All-Union Scientific Center for the Safety of Biologically Active Substances, Kupavna aut NATIONALLICENCE 773 0- Pharmaceutical Chemistry Journal Kluwer Academic Publishers-Plenum Publishers 26/9-10(1992-09-01), 657-676 0091-150X 26:9-10<657 1992 26 11094 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer