caa a22 4500 469110635 CHVBK 20180323133109.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02034799 doi (NATIONALLICENCE)springer-10.1007/BF02034799 Labeling of polyaminomacrocyclic ligands BY99mTcO4− reduction and exchange reactions [Elektronische Daten] [P. Chappuis, S. Truffer, E. Ianoz, P. Lerch] The cationic99mTc-complexes of 1,4,8,12-tetraazacyclopentadecane (15-ane-N4), 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (Me4cyclam) and 1,4,7,10,13,16-hexaazacyclooctadecane (hexacyclen) are obtained in yields higher than 80% by99mTcO 4 − reduction at pH 12. The electrophoretic and chromatographic analyses show that these ligands form structurally similar complexes. Efficient labeling of 15-ane-N4 (>95%) is obtained by the exchange reaction with99mTc-citrate,99mTc-ENDA and99mTc-HBA at pH 12. The labeling yield of hexacyclene is 70% and 85% following the reaction with99mTc-ENDA and99mTc-HBA and99mTc-citrate, respectively. The labeling of Me4cyclam is very poor (about 10%) except starting from99mTc-citrate (55%). The results are compared wint the available data for well characterized [TcO2L]+ complexes. Akadémiai Kiadó, 1992 Chappuis P. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut Truffer S. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut Ianoz E. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut Lerch P. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 163/2(1992-12-01), 255-265 0236-5731 163:2<255 1992 163 10967 https://doi.org/10.1007/BF02034799 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02034799 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chappuis P. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut NATIONALLICENCE 700 1- Truffer S. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut NATIONALLICENCE 700 1- Ianoz E. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut NATIONALLICENCE 700 1- Lerch P. Institut d'Electrochimie et de Radiochimie, Swiss Federal Institute of Technology, Lausanne, Switzerland aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 163/2(1992-12-01), 255-265 0236-5731 163:2<255 1992 163 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer