caa a22 4500 469111836 CHVBK 20180323133113.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02038356 doi (NATIONALLICENCE)springer-10.1007/BF02038356 Using animal dosimetry models to interpret human bioassay data for actinide exposures [Elektronische Daten] [R. Guilmette, A. Eidson] Bioassay and dosometry models are needed to estimate intakes of radionuclides, and to calculate radiation doses to target tissues following such in takes. Because of the diversity of exposure materials, individual biological variabilities, and the general lack of adequate bioassay information and knowledge of the metabolism of radionuclides, current models are based mostly on empiricism. This paper describes biokinetic/dosimetry models for U, Am, and Cm. They are based on experimental data developed from studies in dogs that inhaled one of the above radionuclides in specific chemical forms and specific particle sizes. The models, which are based on similar biological principles, and, therefore, have similar structure, are applied to the very sparse human bioassay data available from cases of exposure to either U, Am, or Cm. The results thus far indicate that the lung retention for the different actinides are well described by the models, that urinary bioassay data can be described within limited time periods, and that the fecal excretion rate is not adequately described. Improvements in modeling are predicted on increased publication of human bioassay data, and better cooperative interaction between model developers and health protection professionals responsible for industrial bioassay programs. Akadémiai Kiadó, 1992 Guilmette R. Inhalation Toxicology Research Institute, P.O. Box 5890, 87185, Albuquerque, NM, (USA) aut Eidson A. Inhalation Toxicology Research Institute, P.O. Box 5890, 87185, Albuquerque, NM, (USA) aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 156/2(1992-01-01), 425-449 0236-5731 156:2<425 1992 156 10967 https://doi.org/10.1007/BF02038356 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02038356 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guilmette R. Inhalation Toxicology Research Institute, P.O. Box 5890, 87185, Albuquerque, NM, (USA) aut NATIONALLICENCE 700 1- Eidson A. Inhalation Toxicology Research Institute, P.O. Box 5890, 87185, Albuquerque, NM, (USA) aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 156/2(1992-01-01), 425-449 0236-5731 156:2<425 1992 156 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer