caa a22 4500 469112867 CHVBK 20180323133116.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02167972 doi (NATIONALLICENCE)springer-10.1007/BF02167972 Synthesis of195mPt radiolabeled (−)-(R)-2-aminomethyl-pyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum(II) monohydrate using high performance liquid chromatography [Elektronische Daten] [K. Kawai, S. Takada, Y. Nakano, W. Ehrlich, H. Maki, M. Akaboshi] An experimental method is described for the synthesis of195mPt-radiolabeled (−)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum (II) (DWA2114R). An amount of 10 mg of 95% enriched194Pt was irradiated for 75 h in the hydraulic conveyer of the KUR at a thermal neutron flux of approximately 8.1×1013 n.cm−2.sec−1 and the195mPt-radiolabeled DWA2114R was purified using HPLC. The chemical yield is higher than 65%, its chemical purity is greater than 99.2%, the radiochemical purity is nearly 100%, and the specific activity is 6.7 MBq. mg−1 DWA2114R. Akadémiai Kiadó, 1992 Kawai K. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut Takada S. Drug Metabolism Center, Chugai Pharmaceutical Co., Ltd., 41-8 Takada, Toshima-ku, 171, Tokyo, Japan aut Nakano Y. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut Ehrlich W. Robert Koch Institute, D-1000, Berlin 65, Germany aut Maki H. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut Akaboshi M. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 164/2(1992-01-01), 123-130 0236-5731 164:2<123 1992 164 10967 https://doi.org/10.1007/BF02167972 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02167972 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawai K. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut NATIONALLICENCE 700 1- Takada S. Drug Metabolism Center, Chugai Pharmaceutical Co., Ltd., 41-8 Takada, Toshima-ku, 171, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakano Y. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut NATIONALLICENCE 700 1- Ehrlich W. Robert Koch Institute, D-1000, Berlin 65, Germany aut NATIONALLICENCE 700 1- Maki H. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut NATIONALLICENCE 700 1- Akaboshi M. Research Reactor Institute, Kyoto University, Kumatori, 590, Sennan, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 164/2(1992-01-01), 123-130 0236-5731 164:2<123 1992 164 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer