caa a22 4500 469113464 CHVBK 20180323133117.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF02037125 doi (NATIONALLICENCE)springer-10.1007/BF02037125 Application of radiotracers with high specific radioactivity to metallotoxicological studies [Elektronische Daten] [E. Sabbioni, M. Bonardi, M. Gallorini, R. Pietra, S. Fortaner, G. Tartaglia, F. Groppi] The use of radiotracers with high specific activity in research on health impact of trace metals overcomes many of the analytical difficulties associated with experimentation carried out at metal levels which are typical of the polluted environment. It allows one to detect and measure ultratrace amounts of metals in biological samples and to follow them into different biochemical compartments, such as subcellular fractions and molecular components. This work shows typical examples of metallotoxicological studies carried out at the JRC-Ispra using radioisotopes with high specific radiactivity produced in the nuclear reactor and in the cyclotron. Applications refer to the use of45Ti,48V,64Cu,95Nb and106mAg in in-vivo and in-vitro studies related to environmental and occupational toxicology research on trace metals. Akadémiai Kiadó, 1992 Sabbioni E. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut Bonardi M. Accelerator and Applied Superconductivity Laboratory, LASA, University and INFN, Via F. lli Cervi 201, 20090, Segrate, Milano, (Italy) aut Gallorini M. CRAA, CNR, Pavia, (Italy) aut Pietra R. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut Fortaner S. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut Tartaglia G. CEC, Institute for Advanced Materials, JRC Petten Establishment, 1755 ZG, Petten, (The Netherlands) aut Groppi F. Accelerator and Applied Superconductivity Laboratory, LASA, University and INFN, Via F. lli Cervi 201, 20090, Segrate, Milano, (Italy) aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 160/2(1992-07-01), 493-503 0236-5731 160:2<493 1992 160 10967 https://doi.org/10.1007/BF02037125 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02037125 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sabbioni E. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut NATIONALLICENCE 700 1- Bonardi M. Accelerator and Applied Superconductivity Laboratory, LASA, University and INFN, Via F. lli Cervi 201, 20090, Segrate, Milano, (Italy) aut NATIONALLICENCE 700 1- Gallorini M. CRAA, CNR, Pavia, (Italy) aut NATIONALLICENCE 700 1- Pietra R. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut NATIONALLICENCE 700 1- Fortaner S. CEC, Environment Institute, JRC-Ispra Site, 21020, Ispra, Varese, (Italy) aut NATIONALLICENCE 700 1- Tartaglia G. CEC, Institute for Advanced Materials, JRC Petten Establishment, 1755 ZG, Petten, (The Netherlands) aut NATIONALLICENCE 700 1- Groppi F. Accelerator and Applied Superconductivity Laboratory, LASA, University and INFN, Via F. lli Cervi 201, 20090, Segrate, Milano, (Italy) aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 160/2(1992-07-01), 493-503 0236-5731 160:2<493 1992 160 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer