caa a22 4500 469114169 CHVBK 20180323133119.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00431038 doi (NATIONALLICENCE)springer-10.1007/BF00431038 Moderate heat treatment of bone allografts [Elektronische Daten] Experimental results of osteointegration [J. Kühne, R. Bartl, C. Hammer, H. Refior, V. Jansson, M. Zimmer] Summary: The use of bone allografts is often essential in orthopedic surgery. Strict donor screening, including HIV testing 3 months postoperatively, is mandatory before a transplant may be used. Yet these measures do not definitely rule out the possibility of HIV transmission, as there is a window period before infection is revealed by blood testing. Accordingly, there is a need for virus inactivation methods that can be used on bone allografts. As radiation treatment and chemical methods have a number of disadvantages, we chose a moderate heat treatment of 65°C for a series of animal experiments. In 12 rabbit femoral condyles, moderate-heattreated bone allografts were implanted into 6-mm drill holes. Twelve normal allografts and 12 empty drill holes served as controls. Radiologic and histological evaluation up to 12 weeks postoperatively revealed slow spontaneous bone remodeling from the rim to the center of the empty cavities. Normal deep frozen allografts were quickly integrated after a short period of osteoclast reaction around the transplant, with occasional bone bridges between host and allgraft. The examination of heattreated allografts showed no differences to the controls, including morphologic aspects and the time course of osteointegration. Five zones of bone repair and osteointegration were distinguished. We conclude that thermal treatment of bone allografts has no adverse effects on osteointegration in the rabbit femoral condyle. Thus, it may contribute to improving safety in human bone transplantation. Springer-Verlag, 1992 Kühne J. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut Bartl R. Department III for Internal Medicine, Ludwig Maximilians University, Munich, Germany aut Hammer C. Institute for Surgical Research, Ludwig Maximilians University, Munich, Germany aut Refior H. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut Jansson V. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut Zimmer M. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 112/1(1992-12-01), 18-22 0936-8051 112:1<18 1992 112 402 https://doi.org/10.1007/BF00431038 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00431038 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kühne J. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 700 1- Bartl R. Department III for Internal Medicine, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 700 1- Hammer C. Institute for Surgical Research, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 700 1- Refior H. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 700 1- Jansson V. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 700 1- Zimmer M. Orthopedic Department, Ludwig Maximilians University, Munich, Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 112/1(1992-12-01), 18-22 0936-8051 112:1<18 1992 112 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer