caa a22 4500 469114193 CHVBK 20180323133119.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00431041 doi (NATIONALLICENCE)springer-10.1007/BF00431041 Ciprofloxacin-impregnated poly- l -lactic acid drug carrier [Elektronische Daten] New aspects of a resorbable drug delivery system in local antimicrobial treatment of bone infections [C. Teupe, R. Meffert, S. Winckler, W. Ritzerfeld, P. Törmälä, E. Brug] Summary: Resorbable poly-l-lactic acid (PLLA) cylinders (3.5 mm diameter, 5 mm in length) carrying 6% of weight ciprofloxacin (Ciprobay, Bayer AG, Leverkusen, FRG) were investigated in vitro to explore their properties as a slow-release antibiotic deposit. Forty bioactive cylinders stored in test tubes were covered with phosphate buffer (pH 7.4 at 37°C) and 40 with fresh human blood plasma and tested under various conditions. For comparison a gentamicin-polymethylmethacrylate (PMMA) chain (Septopal, E. Merck, Darmstadt, FRG) was exposed to similar test conditions. The quantities of ciprofloxacin and gentamicin released were analysed by a microbiological method (bioassay). The concentrations of ciprofloxacin released were analysed by a microbiological method (bioassay). The concentrations of ciprofloxacin released from 40 cyclinder were initially very high (up to 180 mg/1) but they decreased rapidly within the first 5 days (4.2-22.5 mg/l). Early release of gentamicin reached up to 227.5 mg/l but dropped to of 22 mg/l on the 14th day. Complete degradation of the PLLA-cylinders was not seen in the observed period of 92 days. The mean loss of mass was 8.4%, The recovery of incorporated ciprofloxacin was 6.5% on average. Springer-Verlag, 1992 Teupe C. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut Meffert R. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut Winckler S. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut Ritzerfeld W. Institut für Medizinische Mikrobiologie der Westfälischen Wilhelms-Universität Münster, Germany aut Törmälä P. Institute für Plastics Technology, Technican University of Tampere, Finland aut Brug E. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 112/1(1992-12-01), 33-35 0936-8051 112:1<33 1992 112 402 https://doi.org/10.1007/BF00431041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00431041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Teupe C. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut NATIONALLICENCE 700 1- Meffert R. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut NATIONALLICENCE 700 1- Winckler S. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut NATIONALLICENCE 700 1- Ritzerfeld W. Institut für Medizinische Mikrobiologie der Westfälischen Wilhelms-Universität Münster, Germany aut NATIONALLICENCE 700 1- Törmälä P. Institute für Plastics Technology, Technican University of Tampere, Finland aut NATIONALLICENCE 700 1- Brug E. Klinik und Poliklinik für Unfall- und Handchirurgie der Westfälischen Wilhelms-Universität Münster, Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 112/1(1992-12-01), 33-35 0936-8051 112:1<33 1992 112 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer