caa a22 4500 469114371 CHVBK 20180323133120.0 cr unu---uuuuu 170328e19920401xx s 000 0 eng 10.1007/BF00388087 doi (NATIONALLICENCE)springer-10.1007/BF00388087 Inflammatory reactions in primary osteoarthritis of the hip and total hip prosthesis loosening [Elektronische Daten] [B. Greitemann, Bettina Mues, J. Polster, Th. Pauly, C. Sorgt] Summary: In 14 patients [9 with loosened total hip arthroplasty (THA), 5 with primary osteoarthritis], the inflammatory cell infiltrate was characterized in cryostat tissue sections using antibodies against subsets of macrophages and lymphocytes. In all patients the abundance of a mature type macrophage (25F9+) was observed, whereas 27E10+ macrophages, characteristic of acute inflammatory reactions, were not seen in primary osteoarthritis but were found in 4 out of 9 patients with THA loosening. The RM3/1+ macrophage phenotype was seen in some of both sets of patients (osteoarthritis 4/5; THA loosening 4/9). The markers MRP8 and MRP14 typical of immature macrophages, were found in all patients with osteoarthritis and in some (4/9 and 8/9 respectively) of those with THA loosening. IOT4+ T-helper cells were only present in 1/5 5 patients with osteoarthritis and in 2/9 patients with THA loosening. IOT8+ T-suppressor lymphocytes were more frequently present (in 4/5 and 5/9 respectively). The data reveal remarkable differences between the two groups of patients. While the inflammatory infiltrate in patients with osteoarthritis lacks the characteristics of acute inflammation, in patients THA loosening the inflammatory process seems to be determined by periods of acute reactions. The occasional presence particularly of T-helper cells suggests that the inflammatory process is less T-cell but rather macrophage-driven. Springer-Verlag, 1992 Greitemann B. Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut Mues Bettina Institute of Experimental Dermatology, University of Münster, W-4400, Münster, Germany aut Polster J. Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut Pauly Th Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut Sorgt C. Institute of Experimental Dermatology, University of Münster, W-4400, Münster, Germany aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/3(1992-04-01), 138-141 0936-8051 111:3<138 1992 111 402 https://doi.org/10.1007/BF00388087 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00388087 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greitemann B. Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut NATIONALLICENCE 700 1- Mues Bettina Institute of Experimental Dermatology, University of Münster, W-4400, Münster, Germany aut NATIONALLICENCE 700 1- Polster J. Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut NATIONALLICENCE 700 1- Pauly Th Department of General Orthopedics, University of Münster, W-4400, Münster, Germany aut NATIONALLICENCE 700 1- Sorgt C. Institute of Experimental Dermatology, University of Münster, W-4400, Münster, Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/3(1992-04-01), 138-141 0936-8051 111:3<138 1992 111 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer