caa a22 4500 469114460 CHVBK 20180323133120.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00571486 doi (NATIONALLICENCE)springer-10.1007/BF00571486 Intra-articular injections and articular cartilage metabolism [Elektronische Daten] An experimental study in rabbits [J. Neidel, J. Schmidt, M. Hackenbroch] Summary: We studied the effects of repeated intra-articular injections of sterile 140 mM NaCl solution on articular cartilage in adult rabbits. After 20 injections into the knee joints over a period of 4 weeks, chondrocyte glucosaminoglycan synthesis was evenly reduced in all cartilage layers, accompanied by a significant proteoglycan depletion of the matrix which was most marked in the superficial half of the cartilage. These and other changes only partially reversed during a further 4-week period after the injections had been stopped. Our data underline the need for a clear-cut indication for intra-articular injections. The microtrauma caused by injection, in conjunction with the introduction of a carrier solution into the joint, may, at least when repeated at short intervals, lead to measurable damage to the articular cartilage. Springer-Verlag, 1992 Neidel J. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut Schmidt J. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut Hackenbroch M. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/4(1992-07-01), 237-242 0936-8051 111:4<237 1992 111 402 https://doi.org/10.1007/BF00571486 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00571486 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Neidel J. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut NATIONALLICENCE 700 1- Schmidt J. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut NATIONALLICENCE 700 1- Hackenbroch M. Klinik und Poliklinik für Orthopädie der Universität zu Köln, Josef Stelzmannstraße 9, W-5000, Cologne 41, Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/4(1992-07-01), 237-242 0936-8051 111:4<237 1992 111 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer