caa a22 4500 469114673 CHVBK 20180323133121.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00571518 doi (NATIONALLICENCE)springer-10.1007/BF00571518 Braun Ch Abteilung für Unfallchirurgie, Chirurgische Universitätsklinik, W-6650, Homburg/Saar, Germany aut Autogenously vascularised bone allografts [Elektronische Daten] Experimental model of a new bone-muscle composite graft [Ch. Braun] Summary: Conventional bone allografts carry a high incidence of complications such as infections and pseudarthroses due to immunological rejection and avascularity of grafts. In vascularised grafts healing and remodelling of bone is quicker and more complete. However, vascularised allografts need immunosuppression for prevention of rejection with vascular occlusion. Autogenously vascularised allografts are formed after implantation of bone in muscle of the recipient, allowing vascularisation from this muscle. A muscle-bone composite graft is thus obtained that can be transferred as a pedicled or free graft with microvascular anastomosis. In this study donors were DA and recipients Lewis rats. The bone grafts were implanted in the adductor muscles and transferred after 6 weeks into a femoral defect. A higher number of osteocytes were found in the autogenously vascularised group than in non-vascularised grafts. "Creeping substitution” was found in all cortical layers in vascularised grafts, whereas in conventional allografts bone resorption predominated. The experimental data suggest that in rat autogenously vascularised bone allografts show a remodelling pattern comparable with that of conventional vascularised bone autografts. The advantage of the autogenously vascularised bone allograft is that it allows transferral of a vascularised bone allograft together with its well-vascularised recipient bed without immunosuppressive treatment. Springer-Verlag, 1992 Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/5(1992-09-01), 250-254 0936-8051 111:5<250 1992 111 402 https://doi.org/10.1007/BF00571518 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00571518 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Braun Ch Abteilung für Unfallchirurgie, Chirurgische Universitätsklinik, W-6650, Homburg/Saar, Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/5(1992-09-01), 250-254 0936-8051 111:5<250 1992 111 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer