caa a22 4500 469114681 CHVBK 20180323133121.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF00571520 doi (NATIONALLICENCE)springer-10.1007/BF00571520 Collagen stabilization induced by natural humic substances [Elektronische Daten] [U. Riede, I. Jonas, B. Kirn, U. Usener, W. Kreutz, W. Schlickewey] Summary: Humic substances are polyphenolic compounds. They have antiviral as well as desmutagenic effects and react with biopolymers such as collagen; thereby they have no toxic side effects by oral administration. In vitro incubation with humic substances raises the breaking point of the tail tendon of the rat by about 75%. The chemical resistance of the collagen fibres in tail tendon collagen is also increased by in vitro incubation with humic substances, at least insofar as the ultrastructurally and biophysically measurable destruction of the collagen fibres by 4M guanidinium chloride is inhibited. As humic substances increase the mechanical and chemical resistance of collagen fibres and promote their "maturity”, it seems likely that this effect of humic substances depends upon their interaction with the hydrogen bonding and covalent bonding of the collagen fibres. Such a conclusion is confirmed by the results of X-ray diffraction analysis. Springer-Verlag, 1992 Riede U. Department of Pathology, Medical School, University of Freiburg, Freiburg/Br., Germany aut Jonas I. Department of Orthodontics, School of Dentistry, University of Freiburg, Freiburg/Br., Germany aut Kirn B. Department of Biophysics and Radiation Biology, Medical School, University of Freiburg, Freiburg/Br., Germany aut Usener U. Department of Pathology, Medical School, University of Freiburg, Freiburg/Br., Germany aut Kreutz W. Department of Biophysics and Radiation Biology, Medical School, University of Freiburg, Freiburg/Br., Germany aut Schlickewey W. Department of Traumatology, Medical School, University of Freiburg, Freiburg/Br., Germany aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/5(1992-09-01), 259-264 0936-8051 111:5<259 1992 111 402 https://doi.org/10.1007/BF00571520 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00571520 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Riede U. Department of Pathology, Medical School, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 700 1- Jonas I. Department of Orthodontics, School of Dentistry, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 700 1- Kirn B. Department of Biophysics and Radiation Biology, Medical School, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 700 1- Usener U. Department of Pathology, Medical School, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 700 1- Kreutz W. Department of Biophysics and Radiation Biology, Medical School, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 700 1- Schlickewey W. Department of Traumatology, Medical School, University of Freiburg, Freiburg/Br., Germany aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 111/5(1992-09-01), 259-264 0936-8051 111:5<259 1992 111 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer