caa a22 4500 469115084 CHVBK 20180323133122.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF00731093 doi (NATIONALLICENCE)springer-10.1007/BF00731093 Glycosphingolipid expression in spontaneously aborted fetuses and placenta from blood group p women. Evidence for placenta being the primary target for anti-Tja-antibodies [Elektronische Daten] [Karin Lindström, Albert Von Dem Borne, Michael Breimer, Bertil Cedergren, Yasuto Okubo, Lennart Rydberg, Susann Teneberg, Bo Samuelsson] A 12-week-old fetus and one 17-week-old fetus + placenta were obtained after spontaneous abortions from two women of blood group p. The 17-week-old fetus was dissected into intestine, liver, brain and residual tissue. Nonacid glycosphingolipid fractions were prepared from the tissues. Glycolipid characterization was carried out using thin layer chromatography immunostained with monoclonal antibodies and bacteria and by1H NMR spectroscopy and mass spectrometry. In the placental fraction substantial amounts of globotetraosylceramide (P-antigen) and globotriaosylceramide (Pk-antigen) were identified. In contrast, the fetuses contained only trace amounts of these structures, as revealed by immunostaining. These results indicate that the primary target for the antibodies of the anti-Tja serum is the placenta tissue, resulting in termination of the pregnancy. Chapman & Hall, 1992 Blood group p nationallicence glycosphingolipids nationallicence spontaneous abortions nationallicence mass spectrometry nationallicence NMR spectroscopy nationallicence Lindström Karin Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut Von Dem Borne Albert Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, P.O. Box 9190, 1066, Amsterdam, The Netherlands aut Breimer Michael Department of Surgery, Sahlgren's Hospital, S-413 45, Göteborg, Sweden aut Cedergren Bertil Blood Bank, Umeå University Hospital, S-901 85, Umeå, Sweden aut Okubo Yasuto Osaka Red Cross Blood Center, 4-34, Morinomiya, 2-Chome, Joto-Ku, 536, Osaka, Japan aut Rydberg Lennart Regional Blood Center, Sahlgren's Hospital, S-413 45, Göteborg, Sweden aut Teneberg Susann Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut Samuelsson Bo Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut Glycoconjugate Journal Kluwer Academic Publishers 9/6(1992-12-01), 325-329 0282-0080 9:6<325 1992 9 10719 https://doi.org/10.1007/BF00731093 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00731093 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lindström Karin Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut NATIONALLICENCE 700 1- Von Dem Borne Albert Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, P.O. Box 9190, 1066, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Breimer Michael Department of Surgery, Sahlgren's Hospital, S-413 45, Göteborg, Sweden aut NATIONALLICENCE 700 1- Cedergren Bertil Blood Bank, Umeå University Hospital, S-901 85, Umeå, Sweden aut NATIONALLICENCE 700 1- Okubo Yasuto Osaka Red Cross Blood Center, 4-34, Morinomiya, 2-Chome, Joto-Ku, 536, Osaka, Japan aut NATIONALLICENCE 700 1- Rydberg Lennart Regional Blood Center, Sahlgren's Hospital, S-413 45, Göteborg, Sweden aut NATIONALLICENCE 700 1- Teneberg Susann Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut NATIONALLICENCE 700 1- Samuelsson Bo Department of Medical Biochemistry, University of Göteborg, S-413 90, Göteborg, Sweden aut NATIONALLICENCE 773 0- Glycoconjugate Journal Kluwer Academic Publishers 9/6(1992-12-01), 325-329 0282-0080 9:6<325 1992 9 10719 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer