caa a22 4500 469115866 CHVBK 20180323133124.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02735374 doi (NATIONALLICENCE)springer-10.1007/BF02735374 Reduction of bleomycin-induced sequestration of neutrophils and vascular injury in hamster lungs by nitroglycerin [Elektronische Daten] [Q. Wang, D. Haynam, D. Hyde, A. Combs, S. Giri] Neutrophil sequestration within the pulmonary microvasculature contributes to the pathogenesis of various types of lung injury. The present study was designed to test the hypothesis that nitroglycerin, a vasodilator, could decrease neutrophil sequestration within the hamster lung, and thus lead to reduction of bleomycin-induced lung inflammation and injury. Nitroglycerin in an ointment base or petroleum jelly was dermally applied twice daily to the backs of hamsters which were given a single dose of bleomycin or 0.9% NaCl intratracheally. Nitroglycerin significantly reduced the bleomycin-induced increase in neutrophil sequestration in the lungs as indicated by a decrease in the number of neutrophils in bronchoalveolar lavage fluid (BALF), and by both BALF and tissue myeloperoxidase activity. Similarly, nitroglycerin significantly attenuated bleomycin-induced increases in protein content and acid phosphatase activity in the BALF supernatant. There was a marginal, but nonstatistically significant, reduction of bleomycin-induced increases in lung hydroxyproline content and malondialdehyde production by nitroglycerin. It was concluded that nitroglycerin, acting presumably by inducing pulmonary vasodilation, caused a marked reduction in the bleomycin-induced neutrophil sequestration and thus offered protection against the vascular leakage and lung injury in the model. Kluwer Academic Publishers bv, 1992 bleomycin nationallicence nitroglycerin nationallicence neutrophils nationallicence myeloperoxidase nationallicence hamster lung nationallicence Wang Q. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut Haynam D. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut Hyde D. Department of Anatomy, School of Veterinary Medicine, University of California, Davis, CA, USA aut Combs A. Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, Texas, USA aut Giri S. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 249-261 0925-4692 1:3<249 1992 1 10787 https://doi.org/10.1007/BF02735374 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02735374 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Q. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut NATIONALLICENCE 700 1- Haynam D. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut NATIONALLICENCE 700 1- Hyde D. Department of Anatomy, School of Veterinary Medicine, University of California, Davis, CA, USA aut NATIONALLICENCE 700 1- Combs A. Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, Texas, USA aut NATIONALLICENCE 700 1- Giri S. Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis, CA, USA aut NATIONALLICENCE 773 0- InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 249-261 0925-4692 1:3<249 1992 1 10787 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer