caa a22 4500 469115912 CHVBK 20180323133124.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02735370 doi (NATIONALLICENCE)springer-10.1007/BF02735370 Partial liver resection and inflammation: Role of endogenous glucocorticoids [Elektronische Daten] [R. Coimbra, P. Sannomiya, S. Rasslan, J. Garcia-Leme] The early local exudative cellular reaction in an inflammatory lesion (pleurisy) was impaired in partially hepatectomized rats, 5 days postoperatively, whereas splenectomized and sham-operated controls exhibited normal responses. Changes in total plasma protein concentration, prothrombin time and blood glucose levels were not observed in these animals. In contrast, enhanced levels of circulating corticosterone were consistently found in rats undergoing liver resection. This was accompanied by the characteristic eosinopenia evoked by increased concentrations of circulating glucocorticoids. Treatment of hepatectomized animals with metyrapone to block synthesis of glucocorticoids without causing a typical deficiency of mineralocorticoids, resulted in the reversal of previously inhibited inflammatory reactions. Complete recovery of the animals was observed 20 days postoperatively, when 85% of liver tissue was regenerated. It is suggested that liver resection might impair the metabolic capacity of the animals leading to increased levels of circulating glucocorticoids that, in turn, could interfere with the development of inflammatory responses. Kluwer Academic Publishers bv, 1992 liver resection nationallicence inflammation nationallicence glucocorticoids nationallicence Coimbra R. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut Sannomiya P. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut Rasslan S. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut Garcia-Leme J. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 213-222 0925-4692 1:3<213 1992 1 10787 https://doi.org/10.1007/BF02735370 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02735370 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coimbra R. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Sannomiya P. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Rasslan S. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Garcia-Leme J. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 213-222 0925-4692 1:3<213 1992 1 10787 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer