caa a22 4500 469115920 CHVBK 20180323133124.0 cr unu---uuuuu 170328e19920901xx s 000 0 eng 10.1007/BF02735375 doi (NATIONALLICENCE)springer-10.1007/BF02735375 Effects of human recombinant IL-1β on established experimental arthritis in rats [Elektronische Daten] [E. Drelon, P. Gillet, J. Jouzeau, P. Fener, A. Bousseau, G. Charriere, B. Terlain, P. Netter] Abstract 0: Recent studies have reported the ambivalent properties of IL-1, in that it increases or decreases experimental arthritis depending on the dose, the mode, the site, the duration of administration, and the animal model used. In a first experiment we investigated the influence of iterative subcutaneous injections of human recombinant interleukin-1β (HrIL-1β) (0.02, 0.2 or 2 μg) on the inflammatory events in arthritic rats sensitized with type II collagen and muramyl dipeptide. The daily dose of 0.2 μg slightly reduced the pathological response score while 2 μg made it worse; the dose of 0.02 μg was always ineffective. Therefore, the long-term influence of the 0.2 μg dosage of HrIL-1β on the severity of arthritic lesions was investigated. In those experimental conditions, when compared with vehicle only, HrIL-1β slightly reduced hindpaw oedema. This effect was noticeable in severely diseased animals, but was absent in those having moderate swelling. In addition, HrIL-1β induced a delayed relapsing inflammation, whatever the severity of the arthritis. In comparison, indomethacin markedly decreased the early events of inflammation without affecting the delayed relapsing arthritic process. Kluwer Academic Publishers bv, 1992 IL-1 nationallicence cytokines nationallicence rat arthritis nationallicence inflammatory events nationallicence Drelon E. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut Gillet P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut Jouzeau J. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut Fener P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut Bousseau A. Rhône Poulenc Rorer, Centre de Recherches de Vitry/Alfortville, F-94403, Vitry sur Seine, France aut Charriere G. Centre de Radioanalyse, Institut Pasteur, URA CNRS 1459, F-69366, Lyon, France aut Terlain B. Rhône Poulenc Rorer, Centre de Recherches de Vitry/Alfortville, F-94403, Vitry sur Seine, France aut Netter P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 263-282 0925-4692 1:3<263 1992 1 10787 https://doi.org/10.1007/BF02735375 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02735375 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Drelon E. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut NATIONALLICENCE 700 1- Gillet P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut NATIONALLICENCE 700 1- Jouzeau J. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut NATIONALLICENCE 700 1- Fener P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut NATIONALLICENCE 700 1- Bousseau A. Rhône Poulenc Rorer, Centre de Recherches de Vitry/Alfortville, F-94403, Vitry sur Seine, France aut NATIONALLICENCE 700 1- Charriere G. Centre de Radioanalyse, Institut Pasteur, URA CNRS 1459, F-69366, Lyon, France aut NATIONALLICENCE 700 1- Terlain B. Rhône Poulenc Rorer, Centre de Recherches de Vitry/Alfortville, F-94403, Vitry sur Seine, France aut NATIONALLICENCE 700 1- Netter P. Laboratoire de Pharmacologie, URA CNRS 1288, Faculté de Médecine, F-54505, Nancy, France aut NATIONALLICENCE 773 0- InflammoPharmacology Springer Netherlands 1/3(1992-09-01), 263-282 0925-4692 1:3<263 1992 1 10787 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer