caa a22 4500 46911598X CHVBK 20180323133124.0 cr unu---uuuuu 170328e19921201xx s 000 0 eng 10.1007/BF02755883 doi (NATIONALLICENCE)springer-10.1007/BF02755883 Idiopathic chronic facial pain: Tricyclic antidepressant drug action is not due to free radical scavenging (antioxidant) activity [Elektronische Daten] [M. Wasil, B. Henderson, M. Harris] It has recently been suggested that free radicals (oxidants) are involved in stress-related conditions such as chronic idiopathic (psychogenic) facial pain. Tricyclic antidepressants are the drugs of choice in the treatment of this condition. This raises the question as to whether these compounds are acting as antioxidants (free radical scavengers). In this study the antioxidant properties of three tricyclic agents: amitriptyline, nortriptyline and dothiepin have been examined using two distinct assay systems. These involved testing scavenging activity against hypochlorous acid or against the peroxyl radical. None of the compounds tested showed any antioxidant/radical scavenging activity. Our results indicate that the therapeutic activity of these tricyclic antidepressants is not dependent on their ability to function as antioxidants. Kluwer Acedemic Publishers, 1992 free radical scavengers nationallicence tricyclic antidepressants nationallicence facial pain nationallicence Wasil M. Joint Department of Maxillofacial Surgery and Oral Medicine, Institute of Dental Surgery, University of London, UK aut Henderson B. Joint Department of Maxillofacial Surgery and Oral Medicine, Institute of Dental Surgery, University of London, UK aut Harris M. The Eastman Dental Hospital and University College Hospital, 256 Gray's Inn Road, WC1X8LD, London, UK aut InflammoPharmacology Birkhäuser-Verlag 1/4(1992-12-01), 329-335 0925-4692 1:4<329 1992 1 10787 https://doi.org/10.1007/BF02755883 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02755883 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wasil M. Joint Department of Maxillofacial Surgery and Oral Medicine, Institute of Dental Surgery, University of London, UK aut NATIONALLICENCE 700 1- Henderson B. Joint Department of Maxillofacial Surgery and Oral Medicine, Institute of Dental Surgery, University of London, UK aut NATIONALLICENCE 700 1- Harris M. The Eastman Dental Hospital and University College Hospital, 256 Gray's Inn Road, WC1X8LD, London, UK aut NATIONALLICENCE 773 0- InflammoPharmacology Birkhäuser-Verlag 1/4(1992-12-01), 329-335 0925-4692 1:4<329 1992 1 10787 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer