caa a22 4500 469116145 CHVBK 20180323133125.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00172460 doi (NATIONALLICENCE)springer-10.1007/BF00172460 Pineal tumors [Elektronische Daten] [Rita Linggood, Paul Chapman] From 1972-1985, 30 patients with pineal area tumor have been treated with combinations of surgery and irradiation, no patient receiving chemotherapy as a primary recommendation. Patients ranged between 3 and 69 years of age, 18 were male and 12 female. In 18 patients a tissue diagnosis was made initially, 14 patients required shunts before definitive management and in 8 of the 14 tissue diagnosis was made at the same time. Eight patients had no surgical intervention at any time. Patients who have received irradiation have had whole brain irradiation, local field irradiation, or craniospinal irradiation. Two elderly patients died rapidly of their malignant processes before definitive treatment could be given. Only one patient with a non neoplastic lesion was seen. This was a bleed from an AVM with no underlying tumor. One patient with a pineocytoma was not irradiated. Overall, two-thirds of our patients are alive 5 to 15 years after treatment. There has been no surgical mortality and minimal morbidity from biopsy. Late effects of treatment include one patient with mild hearing loss and three patients with endocrinopathies amenable to medical treatment. We believe that tissue diagnosis allows optimal field design and dose recommendations to be made by the radiotherapist in addition to defining prognosis. In our experience, endodermal sinus tumor and pineoblastoma are highly malignant, and in view of their poor prognosis with conventional management consideration of more radical treatment with a possible role for chemotherapy is suggested. Kluwer Academic Publishers, 1992 pineal tumors nationallicence surgery nationallicence radiation therapy nationallicence chemotherapy nationallicence Linggood Rita Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA aut Chapman Paul Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/1(1992-01-01), 85-91 0167-594X 12:1<85 1992 12 11060 https://doi.org/10.1007/BF00172460 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172460 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Linggood Rita Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Chapman Paul Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/1(1992-01-01), 85-91 0167-594X 12:1<85 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer