caa a22 4500 469116188 CHVBK 20180323133125.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF00172458 doi (NATIONALLICENCE)springer-10.1007/BF00172458 Choroid plexus carcinoma — responses to chemotherapy alone in newly diagnosed young children [Elektronische Daten] [Jeffrey Allen, Jeffrey Wisoff, Larry Helson, Jennifer Pearce, Edward Arenson] Choroid plexus carcinoma (CPC) arising in the infant poses several treatment dilemmas. The tumor is often not totally resectable at presentation given its large size and tendency to invade adjacent brain. Because of its predisposition to regrow and metastasize, some form of postoperative cytotoxic therapy is required. Chemotherapy (CHT), as opposed to radiotherapy (RT), has 4 more desirable risk/benefit role in infants, since it is relatively sparing of late neurologic sequelae. Three young male children presented with large intraventricular CPC at 9, 18, and 27 months of age. One child had subarachnoid metastases at diagnosis and the other two had localized disease. Subtotal resections were accomplished and all three required VP shunts. Initial CHT consisted of four monthly courses of cisplatin (20 mg/m2) and etoposide (100 mg/m2), both administered intravenously, daily, for five days. After four courses, two children had complete responses and one had stable disease. Additional CHT was given but one child developed 4 local recurrence and another diffuse CNS metastases. Both died with intratumoral hemorrhages at 5 and 57 months following diagnosis. The third child remains in continuous remission 46 months after diagnosis. None of the children received RT. Chemotherapy may permit long term deferral of RT. More aggressive CHT regimens should be explored in infants with CPC. Kluwer Academic Publishers, 1992 choroid plexus carcinoma nationallicence chemotherapy nationallicence brain tumors nationallicence Allen Jeffrey NYU Medical Center, New York, New York, USA aut Wisoff Jeffrey NYU Medical Center, New York, New York, USA aut Helson Larry Westchester County Medical Center, Valhalla, New York, USA aut Pearce Jennifer Albany Medical Center, Albany, New York, USA aut Arenson Edward The Children's Hospital, Denver, Colorado, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/1(1992-01-01), 69-74 0167-594X 12:1<69 1992 12 11060 https://doi.org/10.1007/BF00172458 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172458 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Allen Jeffrey NYU Medical Center, New York, New York, USA aut NATIONALLICENCE 700 1- Wisoff Jeffrey NYU Medical Center, New York, New York, USA aut NATIONALLICENCE 700 1- Helson Larry Westchester County Medical Center, Valhalla, New York, USA aut NATIONALLICENCE 700 1- Pearce Jennifer Albany Medical Center, Albany, New York, USA aut NATIONALLICENCE 700 1- Arenson Edward The Children's Hospital, Denver, Colorado, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/1(1992-01-01), 69-74 0167-594X 12:1<69 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer