caa a22 4500 469116269 CHVBK 20180323133125.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF00172709 doi (NATIONALLICENCE)springer-10.1007/BF00172709 Does extent of surgery influence outcome for astrocytoma with atypical or anaplastic foci (AAF)? A report from three Radiation Therapy Oncology Group (RTOG) trials [Elektronische Daten] [Walter Curran Jr, Charles Scott, John Horton, James Nelson, Alan Weinstein, Diane Nelson, A. Fischbach, Chu Chang, Marvin Rotman, Sucha Asbell, William Powlis] 103 patients with the diagnosis of AAF were identified from the RT/BCNU arms of 3 RTOG malignant glioma trials. Pre-treatment tumor size was < 5 cm for 48% and ≥ 5 cm for 52%, and tumor sites were frontal lobe in 55%, temporal in 25%, and parietal in 16%. Surgery consisted of biopsy for 30%, partial resection for 56%, and total resection for 14%. Extent of surgery correlated with age, with 81% of patients < 40 undergoing partial/total resection vs. 60% of those over 40 (P = 0.019). The median survival time (MST) of patients undergoing partial/total resection was 49 mo., vs. 18 mo. for those biopsied only (P = 0.002). Patients with frontal location had longer MST than those with non-frontal lesions (MST: 49 vs. 25 mo., P = 0.047), while no survival difference was apparent by univariate analysis of tumor size. Multivariate analysis demonstrated that only younger age, frontal location, and smaller tumor size correlated significantly with extended survival. Extent of surgery was not predictive. The close correlation between young age and extensive surgery obscures the survival advantage for greater surgery seen with univariate analysis. Smaller tumor size and frontal location favorably influence outcome even when adjusted by age. Kluwer Academic Publishers, 1992 anaplastic astrocytoma nationallicence glioma nationallicence surgery nationallicence Curran Jr Walter Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, PA, USA aut Scott Charles Radiation Therapy Oncology Group, Philadelphia, Pennsylvania aut Horton John ECOG, Albany Med Coll, New York aut Nelson James AFIP, Washington aut Weinstein Alan Moorestown, New Jersey aut Nelson Diane Highland Hosp, Rochester, New York aut Fischbach A. LDS Hosp, Salt Lake City, Utah aut Chang Chu Columbia Presbyterian, New York aut Rotman Marvin SUNY, Brooklyn aut Asbell Sucha A Einstein MC, Philadelphia, Pennsylvania, USA aut Powlis William Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, PA, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/3(1992-03-01), 219-227 0167-594X 12:3<219 1992 12 11060 https://doi.org/10.1007/BF00172709 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172709 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Curran Jr Walter Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Scott Charles Radiation Therapy Oncology Group, Philadelphia, Pennsylvania aut NATIONALLICENCE 700 1- Horton John ECOG, Albany Med Coll, New York aut NATIONALLICENCE 700 1- Nelson James AFIP, Washington aut NATIONALLICENCE 700 1- Weinstein Alan Moorestown, New Jersey aut NATIONALLICENCE 700 1- Nelson Diane Highland Hosp, Rochester, New York aut NATIONALLICENCE 700 1- Fischbach A. LDS Hosp, Salt Lake City, Utah aut NATIONALLICENCE 700 1- Chang Chu Columbia Presbyterian, New York aut NATIONALLICENCE 700 1- Rotman Marvin SUNY, Brooklyn aut NATIONALLICENCE 700 1- Asbell Sucha A Einstein MC, Philadelphia, Pennsylvania, USA aut NATIONALLICENCE 700 1- Powlis William Fox Chase Cancer Center, 7701 Burholme Avenue, 19111, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/3(1992-03-01), 219-227 0167-594X 12:3<219 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer