caa a22 4500 469116358 CHVBK 20180323133125.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172659 doi (NATIONALLICENCE)springer-10.1007/BF00172659 Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors [Elektronische Daten] [Hidemitsu Nakagawa, Shigeki Kubo, Akira Murasawa, Shin Nakajima, Yoshikazu Nakajima, Shuichi Izumoto, Toru Hayakawa] Summary: CSF beta-glucuronidase, polyamines and carcinoembryonic antigen (CEA) were analyzed in 16 patients with meningeal carcinomatosis from solid tumor in systemic organs, 27 with benign brain lesions, 18 with primary brain tumors, 14 with metastatic brain tumors and 5 with leptomeningeal dissemination of other malignant diseases. Beta-glucuronidase levels in all cases of meningeal carcinomatosis, meningeal gliomatosis and meningeal lymphoma were higher than 100 μg/dl/hr; on the other hand, levels in all cases of benign brain lesions were below 100 μg/dl/hr. Levels of beta-glucuronidase and polyamines were not high in the cases with positive cytology after tumor resection. Polyamine levels were below 0.05 nmol/ml in all cases after resection of the metastatic brain tumor. Cystic fluid of malignant tumors showed high levels of beta-glucuronidase and polyamines. On the other hand, the levels of polyamines in the cystic fluid of benign tumor were low, although the levels of beta-glucuronidase were high. Some cases of meningeal carcinomatosis with high levels of serum CEA did not show high levels of CSF CEA. For metastatic brain tumors, the cases with intraparenchymal tumors, especially with dural attachment showed high levels of beta-glucuronidase and CEA preoperatively, but they returned to normal after surgery. In cases of meningeal carcinomatosis treated by intrathecal chemotherapy with methotrexate (MTX) and cytosine arabinoside (Ara-C), CSF beta-glucuronidase reflected the neurological status better than the cell count decreased rapidly following chemotherapy and beta-glucuronidase was considered as a useful CSF marker in cases of meningeal carcinomatosis to monitor the course of the disease. The same situation was observed in CSF CEA and CEA was also considered as a useful marker when CEA levels in CSF are higher than those in serum. Kluwer Academic Publishers, 1992 brain tumor nationallicence meningeal carcinomatosis nationallicence cerebrospinal fluid nationallicence biochemical tumor marker nationallicence Nakagawa Hidemitsu Department of Neurosurgery, The Center for Adult Diseases, Osaka 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Kubo Shigeki aut Murasawa Akira aut Nakajima Shin aut Nakajima Yoshikazu aut Izumoto Shuichi aut Hayakawa Toru Department of Neurosurgery, Osaka University Medical School, 50 Fukushima Fukushima-ku, 553, Osaka, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 111-120 0167-594X 12:2<111 1992 12 11060 https://doi.org/10.1007/BF00172659 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172659 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakagawa Hidemitsu Department of Neurosurgery, The Center for Adult Diseases, Osaka 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Kubo Shigeki aut NATIONALLICENCE 700 1- Murasawa Akira aut NATIONALLICENCE 700 1- Nakajima Shin aut NATIONALLICENCE 700 1- Nakajima Yoshikazu aut NATIONALLICENCE 700 1- Izumoto Shuichi aut NATIONALLICENCE 700 1- Hayakawa Toru Department of Neurosurgery, Osaka University Medical School, 50 Fukushima Fukushima-ku, 553, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 111-120 0167-594X 12:2<111 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer