caa a22 4500 469116374 CHVBK 20180323133125.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172670 doi (NATIONALLICENCE)springer-10.1007/BF00172670 Intracerebral (parenchymal) infusion of methotrexate: report of a case [Elektronische Daten] [Kimberly Page, Hannes Vogel, Dikran Horoupian] Summary: This report describes the neuropathological findings in a 32 year old woman with acute myelogenous leukemia (AML) and central nervous system (CNS) involvement, who received a total of 48 mg of methotrexate (MTX) intended to be delivered to the ventricle. At autopsy, the tip of the infusion catheter was found to have been inadvertently placed in the left basal ganglia. The delivery of the MTX at that site caused white matter lesions characteristic of those previously reported in MTX encephalopathy following diverse modes of administration. This case is unusual in that there was the direct infusion of MTX into cerebral parenchyma, circumventing both the blood:brain and cerebrospinal fluid:brain barriers. Axonal abnormalities were widespread in the MTX-infused tissue, frequently but not always accompanied by myelin loss. Since radiation therapy had not been employed, this case permitted the assessment of pathologic changes largely attributable to MTX. Kluwer Academic Publishers, 1992 methotrexate nationallicence neurotoxicity nationallicence leukemia nationallicence axonopathy nationallicence myelinopathy nationallicence Page Kimberly Department of Neurosurgery, Stanford University Medical Center, 94305, Stanford, CA, USA aut Vogel Hannes Department of Pathology (Neuropathology), Stanford University Medical Center, 94305, Stanford, CA, USA aut Horoupian Dikran Department of Pathology (Neuropathology), Stanford University Medical Center, 94305, Stanford, CA, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 181-186 0167-594X 12:2<181 1992 12 11060 https://doi.org/10.1007/BF00172670 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172670 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Page Kimberly Department of Neurosurgery, Stanford University Medical Center, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Vogel Hannes Department of Pathology (Neuropathology), Stanford University Medical Center, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Horoupian Dikran Department of Pathology (Neuropathology), Stanford University Medical Center, 94305, Stanford, CA, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 181-186 0167-594X 12:2<181 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer