caa a22 4500 469116412 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172662 doi (NATIONALLICENCE)springer-10.1007/BF00172662 Adjuvant chemotherapy with carmustine and cisplatin for patients with malignant gliomas [Elektronische Daten] [W. Yung, Todd Janus, Moshe Maor, Lynn Feun] Summary: Forty-five patients with malignant gliomas were treated after aggressive surgical resection with alternating intravenous carmustine and cisplatin both during and after radiation therapy. Thirty-three patients were considered evaluable for responses, 17 had glioblastoma multiforme (GBM),14 had anaplastic astrocytoma (AA) and 2 had anaplastic oligodendroglioma (AO). The median age of the evaluable patients was 47 years. The median time to tumor progression was 34.5 weeks, and the median survival for the entire group was 76 weeks. Early progression occurred more frequently in patients with glioblastoma than in those with AA or AO. Seventeen patients (55%) were alive at 18 months (6 GBM, 9 AA, 2 AO). Toxicity was mainly hematologic, otic and tolerable. The results suggest that further trial is warranted to assess the efficacy of alternating carmustine and cisplatin in conjunction with radiation therapy postoperatively in patients with malignant gliomas. Kluwer Academic Publishers, 1992 malignant gliomas nationallicence chemotherapy nationallicence carmustine nationallicence cisplatin nationallicence Yung W. Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Janus Todd Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Maor Moshe Department of Radiotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Feun Lynn Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 131-135 0167-594X 12:2<131 1992 12 11060 https://doi.org/10.1007/BF00172662 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172662 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yung W. Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Janus Todd Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Maor Moshe Department of Radiotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 700 1- Feun Lynn Department of Neuro-Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 131-135 0167-594X 12:2<131 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer