caa a22 4500 469116447 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172663 doi (NATIONALLICENCE)springer-10.1007/BF00172663 Brain metastases of malignant melanoma in interferon complete responders: clinical and radiological observations [Elektronische Daten] [Ofer Merimsky, Moshe Inbar, Irith Reider-Groswasser, Samario Chaitchik] Summary: Three patients with metastatic malignant melanoma, 2 of whom were males with primary lesion on the shoulder, and a female with primary lesion on the ankle, with Clark's level III-IV, completely responded to interferon-DTIC, but failed in the brain. Radiologically, all the lesions were peripheral in location, and none showed any bleeding tendency. Clinically, these lesions seemed to be resistant to radiotherapy, chemotherapy or steroid treatment, and were the cause of death after a very short survival period. Interferon apparently is inactive against melanoma brain metastases, but does cause CNS symptoms. Because CNS metastases are sometimes the sole site of clinical relapse, and are frequently disabling, prophylactic cranial irradiation (PCI) needs to be studied in high risk patients. Kluwer Academic Publishers, 1992 alpha interferon nationallicence brain metastases nationallicence malignant melanoma nationallicence prophylactic cranial irradiation nationallicence Merimsky Ofer Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut Inbar Moshe Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut Reider-Groswasser Irith Section of Neuroradiology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut Chaitchik Samario Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 137-140 0167-594X 12:2<137 1992 12 11060 https://doi.org/10.1007/BF00172663 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172663 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merimsky Ofer Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut NATIONALLICENCE 700 1- Inbar Moshe Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut NATIONALLICENCE 700 1- Reider-Groswasser Irith Section of Neuroradiology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut NATIONALLICENCE 700 1- Chaitchik Samario Department of Oncology, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 137-140 0167-594X 12:2<137 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer