caa a22 4500 469116463 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172666 doi (NATIONALLICENCE)springer-10.1007/BF00172666 Efficacy of ‘8-drugs-in-one-day' combination in treatment of recurrent GBM patients [Elektronische Daten] [A. Boiardi, A. Silvani, I. Milanesi, G. Broggi, L. Fariselli] Summary: Thirty-five adult recurrent GBM patients, divided randomly in two groups of 19 and 16 cases, had been treated with two regimens of chemotherapy: a) ‘eight-drugs-in-one-day'; b) procarbazine + CCNU + vincristine (PCV) respectively. Chemotherapy was planned at the tumor relapse and delivered as long as tolerated without irreversible sequelae or until the CT scan showed tumor progression. Multiple agents are used simultaneously in the therapeutic approach using ‘eight-in-one' to kill as many heterogeneous cells of malignant glial tumor as possible and minimize the emergence of cellular resistance to chemotherapy. Rate response to chemotherapy and the median adjunctive survival time (6.5 and 6 months, respectively) are not significantly different in the two arms of this study. Our experience with such an aggressive multi-drugs combination ‘eight-in-one-day' was disappointing if compared with less toxic, better tolerated and easy delivered (PCV) regimen. Kluwer Academic Publishers, 1992 chemotherapy nationallicence recurrent glioma nationallicence ‘eight-in-one day' nationallicence Boiardi A. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut Silvani A. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut Milanesi I. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut Broggi G. Dept. of Neurosurgery, Milan aut Fariselli L. Dept. of Radiotherapy, General Hospital ‘Niguarda', Milan, Italy aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 153-158 0167-594X 12:2<153 1992 12 11060 https://doi.org/10.1007/BF00172666 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172666 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boiardi A. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut NATIONALLICENCE 700 1- Silvani A. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut NATIONALLICENCE 700 1- Milanesi I. Dept. of Neurology, Istituto Neurologico ‘C. Besta', Italy aut NATIONALLICENCE 700 1- Broggi G. Dept. of Neurosurgery, Milan aut NATIONALLICENCE 700 1- Fariselli L. Dept. of Radiotherapy, General Hospital ‘Niguarda', Milan, Italy aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 153-158 0167-594X 12:2<153 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer