caa a22 4500 469116471 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920201xx s 000 0 eng 10.1007/BF00172667 doi (NATIONALLICENCE)springer-10.1007/BF00172667 FDG transport and phosphorylation in human gliomas measured with dynamic PET [Elektronische Daten] [Karl Herholz, Jobst Rudolf, Wolf-Dieter Heiss] Twenty-six patients with gliomas of WHO-grades two to four were examined with dynamic positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG). FDG rate constants and derived glucose metabolic rates (MRdyn) were determined in solid tumor tissue and in tumor-free brain tissue. In addition, glucose metabolism was also calculated from single scans recorded 30 to 40 min after injection (MRstat). All three rate constants, K1, k2, and k3, were significantly correlated with MRdyn in tumor-free brain. In contrast, in gliomas only k3 was significantly correlated with MRdyn. The ratio of k3 in tumors to k3 in tumor-free brain was also significantly related to histological tumor grade. The results indicate that FDG uptake in brain tumors is governed by FDG phosphorylation and is rather independent from the variation of FDG transport. A comparison between glucose metabolic rates calculated by an autoradiographic approach (MRstat) with the calculation based on individually fitted rate constants (MRdyn) revealed a very close correlation in spite of a moderate systematic difference in absolute values. Kluwer Academic Publishers, 1992 glioma, (18F)2-fluoro-2-deoxy-D-glucose (FDG) nationallicence positron emission tomography (PET) nationallicence glucose transport nationallicence glucose metabolism nationallicence hexokinase nationallicence Herholz Karl Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut Rudolf Jobst Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut Heiss Wolf-Dieter Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 159-165 0167-594X 12:2<159 1992 12 11060 https://doi.org/10.1007/BF00172667 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172667 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Herholz Karl Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut NATIONALLICENCE 700 1- Rudolf Jobst Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut NATIONALLICENCE 700 1- Heiss Wolf-Dieter Max-Planck-Institut für neurologische Forschung, Gleueler Str. 50, D-5000, Köln 41, Germany aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 12/2(1992-02-01), 159-165 0167-594X 12:2<159 1992 12 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer