caa a22 4500 46911651X CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00172950 doi (NATIONALLICENCE)springer-10.1007/BF00172950 Cerebral infection complicating systemic aspergillosis in acute leukemia: clinical and radiographic presentation [Elektronische Daten] [Joseph Sparano, Rasim Gucalp, Josefina Llena, Franklin Moser, Peter Wiernik] Cerebral fungal infection is becoming an increasingly recognized entity in immunocompromised patients on post-mortem examination. In order to determine the frequency of clinically significant cerebral fungal infection and define its clinical characteristics in a cohort of immunocompromised patients at high risk of fungal infection, the records of 118 patients with acute leukemia were examined for 57 clinical and laboratory features. The characteristics of 26 patients with systemic aspergillosis and acute leukemia were compared to 92 patients with acute leukemia in a control group. Eight of 118 patients (7%) had cerebral infection (seven Aspergillus, on Candida). Patients with systemic aspergillosis were more likely than patients in the control group to have focal neurologic findings (p = 0.02), confusion (p = 0.04), and abnormal computerized tomography (CT) of the brain characterized by single or multiple, enhancing or non-enhancing hypodense lesions (p = 0.02). Patients with systemic aspergillosis were more likely to die in complete remission than patients in the control group (p = 0.003); three of six patients with aspergillosis who died in remission expired as a consequence of cerebral infection. Cerebral infection complicated systemic Aspergillus infection in seven of 26 patients (27%), versus one of 16 patients with systemic Candida infection (6%) (p = NS). The authors conclude, therefore, that systemic aspergillosis complicating acute leukemia is more likely to be associated with confusion, focal neurologic findings, and and abnormal CT scan of the brain, and that these findings suggest the presence of cerebral infection. In addition, cerebral infection commonly complicates the course of systemic aspergillosis, and is a significant cause of morbidity and mortality in patients with acute leukemia. A high index of suspicion is needed to insure early diagnosis and appropriate therapy, particularly in those who achieve remission of their leukemia. Kluwer Academic Publishers, 1992 cerebral aspergillosis nationallicence acute leukemia nationallicence Sparano Joseph The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut Gucalp Rasim The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut Llena Josefina The departments of Neuropathology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut Moser Franklin The departments of Radiology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut Wiernik Peter The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 91-100 0167-594X 13:1<91 1992 13 11060 https://doi.org/10.1007/BF00172950 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172950 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sparano Joseph The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut NATIONALLICENCE 700 1- Gucalp Rasim The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut NATIONALLICENCE 700 1- Llena Josefina The departments of Neuropathology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut NATIONALLICENCE 700 1- Moser Franklin The departments of Radiology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut NATIONALLICENCE 700 1- Wiernik Peter The departments of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, 10467, Bronx, New York, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 91-100 0167-594X 13:1<91 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer