caa a22 4500 469116544 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00172949 doi (NATIONALLICENCE)springer-10.1007/BF00172949 Diagnosis and treatment of patients with meningeal carcinomatosis [Elektronische Daten] [Hidemitsu Nakagawa, Akira Murasawa, Shigeki Kubo, Shin Nakajima, Yoshikazu Nakajima, Shuichi Izumoto, Toru Hayakawa] Summary: The records of thirty-four patients with meningeal carcinomatosis treated at our hospital between 1984 and 1990 were reviewed. The sources, histologies, metastatic lesions outside the central nervous system, the history of the treatment of primary lesions and intraparenchymal of metastatic brain tumors and the period from the diagnosis of primary lesions and the treatment of intraparenchymal metastatic brain tumors to the diagnosis of meningeal carcinomatosis were investigated. Meningeal carcinomatosis was diagnosed and by neurological signs, CSF cytology, CT scan and MRI. Each patient was given a 5 mg single dose of methotrexate (MTX) alone or combined with 20 mg cytosine arabinoside (Ara-C) adminstered by intrathecal injection via an Ommaya reservoir and standard lumbar puncture with or without radiotherapy. Following intrathecal chemotherapy 22 of 29 patients showed symptomatic improvement of meningeal irritation and in 10 of 29 patients with cranial nerve impairment amelioration of symptoms was also observed. Moreover, CSF cytology became negative in 10 of 29 patients after a full course of intrathecal chemotherapy. Neurotoxicity Leukoencephalopathy, a neurotoxic effect of intrathecal chemotherapy was not observed in any of the patients. From these results, MTX in small doses is recommended for intrathecal chemotherapy of meningeal carcinomatosis to prevent neurotoxicity. Kluwer Academic Publishers, 1992 meningeal carcinomatosis nationallicence intrathecal chemotherapy nationallicence Nakagawa Hidemitsu Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Murasawa Akira Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Kubo Shigeki Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Nakajima Shin Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Nakajima Yoshikazu Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Izumoto Shuichi Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut Hayakawa Toru Department of Neurosurgery, Osaka University Medical School, 50 Fukushima, 553, Fukushima-ku, Osaka, Japan aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 81-89 0167-594X 13:1<81 1992 13 11060 https://doi.org/10.1007/BF00172949 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172949 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakagawa Hidemitsu Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Murasawa Akira Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Kubo Shigeki Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Nakajima Shin Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Nakajima Yoshikazu Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Izumoto Shuichi Department of Neurosurgery, The Center for Adult Diseases, Osaka, 3 Nakamichi 1-chome Higashinari-ku, 537, Osaka, Japan aut NATIONALLICENCE 700 1- Hayakawa Toru Department of Neurosurgery, Osaka University Medical School, 50 Fukushima, 553, Fukushima-ku, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 81-89 0167-594X 13:1<81 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer