caa a22 4500 469116560 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00172942 doi (NATIONALLICENCE)springer-10.1007/BF00172942 The MTT assay for chemosensitivity testing of human tumors of the central nervous system [Elektronische Daten] Part II: Evaluation of patient- and drug-specific variables [G. Nikkhah, J. Tonn, O. Hoffmann, H. Kraemer, J. Darling, W. Schachenmayr, R. Schönmayr] Summary: In this study we assessed the influence of patient- and drug-specific parameters in the short-term MTT-chemosensitivity assay in 150 primary cell cultures derived from human brain tumors. In 45 patients the MTT assay was directly compared with the CFA (Colony Forming Assay). Resistance was 10-20% higher in the MTT assay than in the CFA, but there was a good agreement in both assays, that more malignant gliomas had a higher in vitro chemosensitivity against ACNU and BCNU. Overall the results demonstrate, that there is no uniform correlation between the in vitro chemosensitivity and the histopathological classification of the tumors, which corresponds well to the clinical situation. On the basis of this study we suggest prospective clinical trials with the MTT assay in human brain tumors. Parts of this paper have been presented at the 63th annual meeting of the ‘Deutsche Gesellschaft für Neurologie', September 13-15, 1990, in Darmstadt, Germany Kluwer Academic Publishers, 1992 brain tumor nationallicence MTT assay nationallicence CFA nationallicence in vitro chemosensitivity nationallicence cell culture nationallicence Nikkhah G. Institute of Neuropathology, Giessen, Germany aut Tonn J. Departments of Neurosurgery, Giessen, Germany aut Hoffmann O. Departments of Neurosurgery, Giessen, Germany aut Kraemer H. Behring Werke A G, Marburg, Germany aut Darling J. Institute of Neurology, London, UK aut Schachenmayr W. Institute of Neuropathology, Giessen, Germany aut Schönmayr R. Nordstadt Hospital, Hannover, Germany aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 13-24 0167-594X 13:1<13 1992 13 11060 https://doi.org/10.1007/BF00172942 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172942 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nikkhah G. Institute of Neuropathology, Giessen, Germany aut NATIONALLICENCE 700 1- Tonn J. Departments of Neurosurgery, Giessen, Germany aut NATIONALLICENCE 700 1- Hoffmann O. Departments of Neurosurgery, Giessen, Germany aut NATIONALLICENCE 700 1- Kraemer H. Behring Werke A G, Marburg, Germany aut NATIONALLICENCE 700 1- Darling J. Institute of Neurology, London, UK aut NATIONALLICENCE 700 1- Schachenmayr W. Institute of Neuropathology, Giessen, Germany aut NATIONALLICENCE 700 1- Schönmayr R. Nordstadt Hospital, Hannover, Germany aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 13-24 0167-594X 13:1<13 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 469116560 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer