caa a22 4500 469116579 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF00172947 doi (NATIONALLICENCE)springer-10.1007/BF00172947 The treatment of adult supratentorial high grade astrocytomas [Elektronische Daten] [Graeme Duncan, George Goodman, Charles Ludgate, Dorianne Rheaume] Summary: From 1 January, 1982 until 31 December, 1987 260 adult patients were referred to the Cancer Control Agency of B.C. with high grade supratentorial astrocytomas. Multifocal disease on presentation was present in 17 cases (6.5%). Their survival is poor and whole brain radiotherapy is required. All other cases had unifocal disease, but eight did not receive radiotherapy. The 235 cases who received radiotherapy were subject to univariate and multivariate analyses according to extent of surgery, age, Kernohan and WHO grading, Karnofsky performance status, whole brain treatment, partial brain treatment, total dose and neuroret. Age is an extremely important predictor of survival (P = 0). The pathologic appearance of glioblastoma (WHO grade) as well as the Karnofsky performance status were also important independent factors in predicting survival (P = 0.016, 0.027 respectively) on Cox multivariate analysis. Dose and neurorets were significant factors only in cases where the performance status was not recorded, suggesting that dose was selected according to the patient's condition and age. In this analysis it was found that localized radiation fields may be used rather than whole brain without jeopardizing survival. Kluwer Academic Publishers, 1992 high grade astrocytoma nationallicence glioblastoma nationallicence radiation therapy nationallicence multivariate analysis nationallicence partial brain versus whole brain nationallicence Duncan Graeme Division of Radiation Oncology, British Columbia Cancer Agency, USA aut Goodman George Developmental Radiotherapy Department, TRIUMF, British Columbia Cancer Agency, U.S.A. aut Ludgate Charles aut Rheaume Dorianne Division of Radiation Oncology, British Columbia Cancer Agency, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 63-72 0167-594X 13:1<63 1992 13 11060 https://doi.org/10.1007/BF00172947 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172947 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duncan Graeme Division of Radiation Oncology, British Columbia Cancer Agency, USA aut NATIONALLICENCE 700 1- Goodman George Developmental Radiotherapy Department, TRIUMF, British Columbia Cancer Agency, U.S.A aut NATIONALLICENCE 700 1- Ludgate Charles aut NATIONALLICENCE 700 1- Rheaume Dorianne Division of Radiation Oncology, British Columbia Cancer Agency, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/1(1992-05-01), 63-72 0167-594X 13:1<63 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer