caa a22 4500 469116609 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00172479 doi (NATIONALLICENCE)springer-10.1007/BF00172479 Pre-radiation chemotherapy in glioma patients with poor prognostic factors [Elektronische Daten] [Kjell Watne, Ole Nome, Bjarne Hager, Henry Hirschberg] Summary: Nineteen patients in an age group from 56-67 years (mean age 62,5 years) with histologically verified glioblastoma multiforme were treated with chemotherapy consisting of two cycles of oral CCNU, intravenous vincristine and oral procarbazine prior to radiation therapy. Ten of the patients had stable disease, monitored by CT scan and neurological examination, and received whole brain radiation. The median survival was 12 months. Nine patients who had progressive disease during chemotherapy did not receive radiation treatment and were put on palliative treatment with dexamethasone. This group had a median survival of 3 months. The median survival in all of the 19 patients who entered the study was 9 months which was comparable to the survival of 56 patients with glioblastoma multiforme who, in a retrospective study, received post-operative radiotherapy. The most important factor predicting survival was steroid-dependency after surgery. Kluwer Academic Publishers, 1992 glioblastoma multiforme nationallicence pre-radiation chemotherapy nationallicence vincristine nationallicence CCNU nationallicence procarbazine nationallicence Watne Kjell The Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway aut Nome Ole The Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway aut Hager Bjarne The Department of Radiology, The Norwegian Radium Hospital, Oslo, Norway aut Hirschberg Henry Department of Neurosurgery, The National Hospital, Oslo, Norway aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 261-264 0167-594X 13:3<261 1992 13 11060 https://doi.org/10.1007/BF00172479 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172479 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watne Kjell The Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Nome Ole The Department of Oncology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Hager Bjarne The Department of Radiology, The Norwegian Radium Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Hirschberg Henry Department of Neurosurgery, The National Hospital, Oslo, Norway aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 261-264 0167-594X 13:3<261 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer