caa a22 4500 469116641 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00172481 doi (NATIONALLICENCE)springer-10.1007/BF00172481 Proliferative potential and outcome in pediatric astrocytic tumors [Elektronische Daten] [Michael Prados, Hendrikus Krouwer, Michael Edwards, Philip Cogen, Richard Davis, Takao Hoshino] Summary: In 43 pediatric patients (29 male, 14 female) with primary astrocytic tumors of the central nervous system (CNS), the correlation was evaluated between outcome and proliferative potential, measured by the bromodeoxyuridine (BrdU) labeling index (LI). Twenty-five patients had low-grade gliomas, 13 had anaplastic gliomas, and 5 had glioblastomas multiforme (GBM). All patients underwent surgery; 37 also had chemotherapy, radiation therapy, or both. The median BrdU LIs were < 1% (range 0-9.3%) in low-grade gliomas, 2.3% (range 0-21.2%) in anaplastic gliomas, and 7.7% (range 0-21.3%) in GBM. Seven of eight patients with BrdU LI > 5% have died (median survival 29 weeks). Median survival has not been reached in patients with BrdU LI <1% (19/22 alive) or between 1% and 5% (12/13 alive) after median follow-up periods of 165 and 120 weeks, respectively. A high BrdU LI correlated with short survival (p = 0.0001); the association between malignant histology and short survival was weaker (p = 0.019). BrdU LI is therefore a significant predictor of outcome in patients with primary CNS astrocytomas and appears to be a stronger predictor than histology in patients with low-grade and anaplastic gliomas. More patients need to be studied to confirm these preliminary observations. Kluwer Academic Publishers, 1992 labeling index nationallicence pediatric nationallicence astrocytoma nationallicence bromodeoxyuridine nationallicence Prados Michael Division of Neuro-Oncology, University of California, 94143, San Francisco, CA, USA aut Krouwer Hendrikus Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut Edwards Michael Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut Cogen Philip Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut Davis Richard Department of Pathology, School of Medicine, University of California, 94143, San Francisco, CA, USA aut Hoshino Takao Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 277-282 0167-594X 13:3<277 1992 13 11060 https://doi.org/10.1007/BF00172481 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172481 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prados Michael Division of Neuro-Oncology, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Krouwer Hendrikus Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Edwards Michael Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Cogen Philip Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Davis Richard Department of Pathology, School of Medicine, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 700 1- Hoshino Takao Brain Tumor Research Center of the Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 277-282 0167-594X 13:3<277 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer