caa a22 4500 469116684 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00172482 doi (NATIONALLICENCE)springer-10.1007/BF00172482 Intracranial ependymoma in children: analysis of prognostic factors [Elektronische Daten] [Joseph Chiu, Shiao Woo, Joann Ater, John Connelly, Janet Bruner, Moshe Maor, Jan van Eys, Mary Oswald, Rick Shallenberger] Summary: Between 1955 and 1986, 25 children (aged 2 weeks to 15 years) were treated for intracranial ependymoma at M.D. Anderson Cancer Center. Nine patients had supratentorial primaries (5 high-grade, 4 low-grade), and 16 had infratentorial primaries (9 high-grade, 7 low-grade). Five patients had gross complete resection and 20 had incomplete resection. Seven patients received craniospinal irradiation (25-36 Gy to the neuroaxis, 45-55 Gy to tumor bed), 12 received local field irradiation (29-60 Gy, median 50 Gy). Five infants had adjuvant chemotherapy without radiotherapy, and 6 children had postradiotherapy adjuvant chemotherapy, and 12 patients had salvage chemotherapy with various agents and number of courses. Eight patients are alive, disease-free and without relapse from 1 year to 12 1/2 years from diagnosis (median 42 months). The primary failure pattern was local recurrence. The data suggest that 1) the long-term cure rate of children with ependymoma is suboptimal; 2) histologic grade may be of prognostic importance for supratentorial tumors; 3) prognosis appears worse for girls and infants under 3 years of age; 4) in well-staged patients routine spinal irradiation could be omitted; 5) the role of adjuvant chemotherapy is unclear. Kluwer Academic Publishers, 1992 ependymoma nationallicence children nationallicence prognostic factors nationallicence Chiu Joseph Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Woo Shiao Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Ater Joann Pediatrics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Connelly John Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Bruner Janet Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Maor Moshe Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut van Eys Jan Pediatrics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Oswald Mary Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Shallenberger Rick Patient Studies, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 283-290 0167-594X 13:3<283 1992 13 11060 https://doi.org/10.1007/BF00172482 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172482 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chiu Joseph Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Woo Shiao Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Ater Joann Pediatrics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Connelly John Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Bruner Janet Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Maor Moshe Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- van Eys Jan Pediatrics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Oswald Mary Departments of Clinical Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Shallenberger Rick Patient Studies, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Texas, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 283-290 0167-594X 13:3<283 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer