caa a22 4500 469116692 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00172474 doi (NATIONALLICENCE)springer-10.1007/BF00172474 Histologic factors in the grading and prognosis of astrocytoma grade I-IV [Elektronische Daten] [Ewald Rutten, Wim Doesburg, Joop Slooff] Summary: The prognostic value of histologic or cytologic features were examined in 317 patients with an astrocytic glioma. Of 46 features examined 7 morphologic characteristics of nucleus and 5 of mesenchyma correlated well with grading according to Kernohan. The morphological characteristics of nucleus are cellularity, atypical nuclei, polymorphism, multinucleated cells, hyperchromasia, gigantic nuclei and mitosis. For mesenchyma these were vascularity, vascular endothelial proliferation, vascular glomeruli, necrosis with palisade formation and necrosis without palisade formation. Scoring of these items on a scale from 0 to 4 enables us to establish a nucleus-score (max. 28) and a mesenchyma-score (max. 20). Nucleus-score + mesenchyma-score ≤ 10 corresponds with astrocytoma grade II, ≤ 20 with grade III and > 20 with grade IV. A low nucleus-score in grade II (< 5) predicts a long survival (> 10 years), a high nucleus-score a low survival (median 0.6 year). In grade III a low mesenchyma-score predicts a median survival of 1.25 years, a high mesenchyma-score a median survival of 0.38 year. This retrospective study shows that nucleus-score and mesenchyma-score correlate to grading according to Kernohan and are highly correlative to survival. Kluwer Academic Publishers, 1992 brain neoplasms nationallicence astrocytoma nationallicence therapeutic radiology nationallicence diagnosis nationallicence Rutten Ewald Department of Radiotherapy, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Doesburg Wim Department of Medical Statistics, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Slooff Joop Department of Pathology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 223-230 0167-594X 13:3<223 1992 13 11060 https://doi.org/10.1007/BF00172474 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172474 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rutten Ewald Department of Radiotherapy, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Doesburg Wim Department of Medical Statistics, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Slooff Joop Department of Pathology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 223-230 0167-594X 13:3<223 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer