caa a22 4500 469116722 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920701xx s 000 0 eng 10.1007/BF00172483 doi (NATIONALLICENCE)springer-10.1007/BF00172483 Effect of intra-arterial cisplatin and 1,3-bis(2chloroethyl)-1-nitrosourea (BCNU) dosage on radiographic response and regional toxicity in malignant glioma patients: proposal of a new method of intra-arterial dosage calculation [Elektronische Daten] [Hunt Bobo, John Kapp, Ralph Vance] Summary: The frequency of both neurologic toxicity and therapeutic response due to intra-arterial (IA) chemotherapy is decreased by dose reduction. A method to individualize IA drug dosage is needed to provide each patient with the safest, most effective dose. Most trials of IA chemotherapy for malignant glioma have used body surface area (BSA) to calculate dosage; but brain size and arterial distribution do not correlate well with BSA. Fixed doses of cisplatin and BCNU were used in combination to perform 35 IA infusions in 20 malignant gliomas patients. Doses modified by the number of major intracranial vessels supplied by the infused artery were used in 34 infusions in 19 patients. Patients receiving 150 to 200 mg CP and 300 mg BCNU had an incidence of neurologic deficit of 5.6% if ≥ 3 vessels were supplied by the infused artery compared to 42% for those with only 2 vessels. This crude dose modification maintained efficacy while reducing neurologic toxicity. Further refinement is possible using well established intra-arterial pharmacokinetic principles. Intra-arterial dosing based on volume flow at the site of infusion would yield a more reproducible exposure of the infused capillary bed to a drug than methods currently in use. More consistent drug exposure should reduce toxicity due to over dosing and treatment failure due to under dosing. Kluwer Academic Publishers, 1992 dosage calculation nationallicence intra-arterial chemotherapy nationallicence neurotoxicity nationallicence malignant glioma nationallicence pharmacokinetics nationallicence dosing nationallicence Bobo Hunt Department of Neurosurgery, University of Mississippi, USA aut Kapp John Department of Neurosurgery, University of Mississippi, USA aut Vance Ralph University of Mississippi, Division of Medical Oncology, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 291-299 0167-594X 13:3<291 1992 13 11060 https://doi.org/10.1007/BF00172483 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172483 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bobo Hunt Department of Neurosurgery, University of Mississippi, USA aut NATIONALLICENCE 700 1- Kapp John Department of Neurosurgery, University of Mississippi, USA aut NATIONALLICENCE 700 1- Vance Ralph University of Mississippi, Division of Medical Oncology, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/3(1992-07-01), 291-299 0167-594X 13:3<291 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer