caa a22 4500 469116749 CHVBK 20180323133126.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172763 doi (NATIONALLICENCE)springer-10.1007/BF00172763 Temporal trends among childhood brain tumor biopsies [Elektronische Daten] [F.H. Gilles, E.L. Sobel, A. Leviton, E.T. Hedley-Whyte, C.J. Tavare, L. Adelman, R.A. Sobel] We sought temporal trends in the demographic, clinical, histologic feature, diagnostic class, and quality of life data over the interval 1930-1979 in the Childhood Brain Tumor Consortium database. The proportion of children younger than eight years old declined from 72% to 55% and the proportion of those older than ten more than doubled from 12% to 27%. The relative frequency of tumors in the supratentorial compartment increased significantly, while infratentorial tumors decreased. We found significant declines in supratentorial ependymomas and pilocytic astrocytomas. Similarly, some infratentorial tumors, especially ependymomas, decreased and brain stem tumors increased. Infratentorial medulloblastoma (primitive neuroectodermal tumor) increased significantly. Some individual histologic features which are markers of anaplasia increased in frequency in both supratentorial and infratentorial tumors. There was a significant increase in biopsies that contained nonneoplastic neural tissue in addition to tumor for both compartments and among supratentorial tumors there was a marked increase in the proportion of cases containing an indistinct neural tissue boundary. The probability of postoperative death declined, but the probability of survival five or ten years after surgery did not improve significantly for children who had tumors in either compartment. Among children who survived five years after the initial craniotomy, the proportion who had significant long term deficits increased. Most of this increase occurred in the last decade (1970-79). In this decade, the proportion of children for whom no deficits were reported five years following operation was 4% if they had a supratentorial tumor and 27% if they had an infratentorial tumor. The proportions of children alive five years following first surgery who had arachnoidal metastases increased significantly for infratentorial tumors. Kluwer Academic Publishers, 1992 brain tumors nationallicence children nationallicence ependymoma nationallicence astrocytoma nationallicence medulloblastoma nationallicence time nationallicence temporal (secular) trends nationallicence epidemiology nationallicence survival nationallicence symptoms nationallicence age distribution nationallicence sequelae of brain tumors nationallicence Gilles F.H. The Childhood Brain Tumor Consortium, USA aut Sobel E.L. The Childhood Brain Tumor Consortium, USA aut Leviton A. The Childhood Brain Tumor Consortium, USA aut Hedley-Whyte E.T. The Childhood Brain Tumor Consortium, USA aut Tavare C.J. The Childhood Brain Tumor Consortium, USA aut Adelman L. The Childhood Brain Tumor Consortium, USA aut Sobel R.A. The Childhood Brain Tumor Consortium, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 137-149 0167-594X 13:2<137 1992 13 11060 https://doi.org/10.1007/BF00172763 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172763 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilles F.H. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Sobel E.L. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Leviton A. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Hedley-Whyte E.T. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Tavare C.J. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Adelman L. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 700 1- Sobel R.A. The Childhood Brain Tumor Consortium, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 137-149 0167-594X 13:2<137 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer