caa a22 4500 469116765 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172770 doi (NATIONALLICENCE)springer-10.1007/BF00172770 Low grade gliomas: comparison of intraoperative ultrasound characteristics with preoperative imaging studies [Elektronische Daten] [Peter Le Roux, Mitchel Berger, Keith Wang, Laurence Mack, George Ojemann] Thirty-three patients with low grade gliomas were evaluated with preoperative computed tomography (CT), magnetic resonance (MR) and intraoperative ultrasound (IOUS). Six patients had undergone previous surgical exploration. Tumor borders were marked with cortical letters and corresponding depths calculated. Resection of tumor corresponded to these ultrasound dimensions. The histology of biopsy specimens from tumor and ultrasound determined margins was studied on formalin fixed permanent sections using hematoxylin and eosin (H&E) and immunocytochemistry (GFAP). Tumors were all seen on preoperative MR studies and most commonly showed a decreased T1 and increased T2 signal. Seven tumors showed variable enhancement with gadolinium. On CT two tumors were not seen, twenty-three tumors were hypodense and eight hyperdense. Three tumors showed variable CT contrast enhancement. All tumors were hyperechoic on ultrasound. Twenty-five (75%) tumors were well defined with distinct margins compared to adjacent brain. Eight tumors had poorly defined borders on ultrasound; five (62%) of these lesions had previously undergone surgeery. Eight tumors invaded functional brain identified by stimulation mapping techniques (e.g., speech cortex), thus limiting the resection. Five resections were limited because of involvement of important anatomical structures (e.g., corpus callosum). Of the remaining 20 tumors, seventeen (85%) had ultrasound defined margins that were histologically free of solid tumor (normal brain or sparse atypical cells only). Low grade gliomas are readily identified and their margins well defined by intraoperative ultrasound regardless of preoperative imaging patterns. The results suggest that IOUS may enhance intraoperative delineation and extent of resection for low grade gliomas. Kluwer Academic Publishers, 1992 brain neoplasm nationallicence computed tomography nationallicence glioma nationallicence magnetic resonance image nationallicence ultrasonography nationallicence Le Roux Peter Departments of Neurological Surgery, University of Washington, Seattle, USA aut Berger Mitchel Departments of Neurological Surgery, University of Washington, Seattle, USA aut Wang Keith Departments of Radiology, University of Washington, Seattle, USA aut Mack Laurence Departments of Radiology, University of Washington, Seattle, USA aut Ojemann George Departments of Neurological Surgery, University of Washington, Seattle, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 189-198 0167-594X 13:2<189 1992 13 11060 https://doi.org/10.1007/BF00172770 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172770 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Le Roux Peter Departments of Neurological Surgery, University of Washington, Seattle, USA aut NATIONALLICENCE 700 1- Berger Mitchel Departments of Neurological Surgery, University of Washington, Seattle, USA aut NATIONALLICENCE 700 1- Wang Keith Departments of Radiology, University of Washington, Seattle, USA aut NATIONALLICENCE 700 1- Mack Laurence Departments of Radiology, University of Washington, Seattle, USA aut NATIONALLICENCE 700 1- Ojemann George Departments of Neurological Surgery, University of Washington, Seattle, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 189-198 0167-594X 13:2<189 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer