caa a22 4500 469116781 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172765 doi (NATIONALLICENCE)springer-10.1007/BF00172765 The role of radiotherapy in the treatment of subtotally resected benign meningiomas [Elektronische Daten] [R. Miralbell, R. Linggood, S. de la Monte, K. Convery, J. Munzenrider, R. Mirimanoff] Summary: Thirty-six patients with benign meningioma were treated for primary or recurrent disease by subtotal resection and external beam irradiation from 1968-1986 at Massachusetts General Hospital. Comparison is made with 79 patients treated by subtotal surgery alone from 1962-1980. Progression-free survival for 17 patients irradiated after initial incomplete surgeery was 88% at 8 years compared with 48% for similar patients treated by surgery alone (p = 0.057). 16 patients incompletely resected at time of first recurrence were irradiated and 78% were progression-free at 8 years while 11% of a similar group treated by surgery alone were progression free (p = 0.001). Long term overall survival was high and similar in both control and study groups. Two patients were irradiated at second recurrence and 1 patient at third recurrence. Twenty-five patients were treated with photons alone and have a median follow-up of 57 months, 6 patients have recurred at doses 45-60 Gy. Eleven patients were treated with combined 10 MV photons and 160 MV protons utilizing 3-D treatment planning. These patients have been followed for a median of 53 months and none have failed to date. Eight of 11 received 54-60.4 Gy and 3/11 > 64.48 Gy. Sex, age, pathology grade and score, surgery and timing of radiation therapy were not associated with significant differences in failure patterns within the irradiated study group (p < 0.1). Complications have been seen in 6 irradiated patients. Kluwer Academic Publishers, 1992 benign meningioma nationallicence irradiation nationallicence treatment planning nationallicence dose and outcome nationallicence Miralbell R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Linggood R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut de la Monte S. Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Convery K. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Munzenrider J. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Mirimanoff R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 157-164 0167-594X 13:2<157 1992 13 11060 https://doi.org/10.1007/BF00172765 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172765 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miralbell R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Linggood R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- de la Monte S. Departments of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Convery K. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Munzenrider J. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 700 1- Mirimanoff R. Departments of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 157-164 0167-594X 13:2<157 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 439372623 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer