caa a22 4500 46911679X CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172761 doi (NATIONALLICENCE)springer-10.1007/BF00172761 Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism [Elektronische Daten] [HJJA Bernsen, A Heerschap, AJ van der Kogel, JJ van Vaals, MJJ Prick, EFJ Poels, J Meyer, JA Grotenhuis] In this study a human glioma-derived intracerebral tumor model was analyzed histologically and examined by image-guided 1H NMR spectroscopy. It was shown that histological characteristics such as cellular subpopulation and necrosis of the primary tumor were preserved in the implants. Usually circumscript tumor growth was present with tumor cells invading the surrounding brain parenchyma. It was demonstrated that tumor growth and tumor metabolism could be monitored by image-guided 1H NMR spectroscopy in a longitudinal study. One of the initial changes noticed was the rise of the lactate signal in the tumor region followed by an increase of the choline and a decrease of N-acetyl-aspartate and phosphocreatine signals. Even before tumor invasion in brain adjacent to the central tumor area could be demonstrated by NMR imaging increased lactate and moderately increased choline signals were measured in these regions. By histopathological examination these areas were shown to be infiltrated by single tumor cells. These observations indicate that image-guided 'H NMR spectroscopy could play an important role in the study of brain tumor biology, especially in the case of changing tumor metabolism during growth. Kluwer Academic Publishers, 1992 human brain tumor model nationallicence NMR spectroscopy nationallicence tumor metabolism nationallicence Bernsen HJJA Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut Heerschap A. Philips Research Laboratories, Eindhoven, The Netherlands aut van der Kogel AJ Inst. of Radiotherapy, University of Nijmegen, The Netherlands aut van Vaals JJ Philips Research Laboratories, Eindhoven, The Netherlands aut Prick MJJ Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut Poels EFJ Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut Meyer J. Department of Neuropathology, Canisius Withelmina Hospital, Nijmegen, The Netherlands aut Grotenhuis JA Department of Neurosurgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 119-130 0167-594X 13:2<119 1992 13 11060 https://doi.org/10.1007/BF00172761 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172761 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bernsen HJJA Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Heerschap A. Philips Research Laboratories, Eindhoven, The Netherlands aut NATIONALLICENCE 700 1- van der Kogel AJ Inst. of Radiotherapy, University of Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van Vaals JJ Philips Research Laboratories, Eindhoven, The Netherlands aut NATIONALLICENCE 700 1- Prick MJJ Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Poels EFJ Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Meyer J. Department of Neuropathology, Canisius Withelmina Hospital, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Grotenhuis JA Department of Neurosurgery, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 119-130 0167-594X 13:2<119 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer