caa a22 4500 469116811 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172762 doi (NATIONALLICENCE)springer-10.1007/BF00172762 Treatment of malignant gliomas with surgery, intraarterial chemotherapy with ACNU and radiation therapy [Elektronische Daten] [Felipe Vega, Luis Davila, Gilles Chatellier, Jacques Chiras, François Fauchon, Philippe Cornu, Laurent Capelle, Michel Poisson, Jean Delattre] Summary: Fourty patients with malignant supratentorial gliomas received iterative intraarterial (IA) infusions of ACNU, 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea at a dose of 150 mg repeated every 6 weeks. Group A consisted of eighteen patients previously treated with surgery, radiation therapy (RT) and sometimes chemotherapy, who received IA ACNU at tumor recurrence. Group B consisted of twenty two patients who received IA ACNU in the postoperative pre-RT period. In group A, 8/18 patients (44%) had an objective response, including 6/12 anaplastic astrocytomas (AA) and 2/6 glioblastoma multiforme (GBM), while 10/18 patients (56%) did not respond. Median survival time was 6 months for GBM and 12 months for AA. In group B, 6/22 patients (27%) had an objective response (4/18 GBM and 2/4 AA) and 16/22 patients (73%) did not respond. Nine patients had such an extensive tumor after one or two courses of IA ACNU that RT was cancelled. Median survival time was 8 months for GBM and 8 months for AA. Three patients (8%) had ophthalmologic toxicity on the infused side. There was no case of leukoencephalopathy. Kluwer Academic Publishers, 1992 ACNU nationallicence intraarterial chemotherapy nationallicence malignant gliomas nationallicence Vega Felipe Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Davila Luis National Institute of Neurology and Neurosurgery, Mexico aut Chatellier Gilles Departments of Biostatistics, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Chiras Jacques Departments of Neuroradiology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Fauchon François Departments of Radiation Therapy, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Cornu Philippe Departments of Neurosurgery, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Capelle Laurent Departments of Neurosurgery, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Poisson Michel Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Delattre Jean Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 131-135 0167-594X 13:2<131 1992 13 11060 https://doi.org/10.1007/BF00172762 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172762 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vega Felipe Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Davila Luis National Institute of Neurology and Neurosurgery, Mexico aut NATIONALLICENCE 700 1- Chatellier Gilles Departments of Biostatistics, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Chiras Jacques Departments of Neuroradiology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Fauchon François Departments of Radiation Therapy, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Cornu Philippe Departments of Neurosurgery, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Capelle Laurent Departments of Neurosurgery, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Poisson Michel Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 700 1- Delattre Jean Departments of Neurology, Groupe Hospitalier Pitié-Salpètrière, Paris, France aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 131-135 0167-594X 13:2<131 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer