caa a22 4500 469116854 CHVBK 20180323133127.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF00172766 doi (NATIONALLICENCE)springer-10.1007/BF00172766 Neurotropic melanoma [Elektronische Daten] A case report and review of the literature [Ellen Mack, Edward Gomez] Neurotropic melanoma is a rare tumor with a biphasic growth pattern associated with a change in morphology from melanocytic features toward Schwann cell features. The tumor thereby develops a capacity for infiltrating nerves which may result in clinically evident cranial neuropathies, most commonly of the fifth and seventh cranial nerves. The histology of this lesion is difficult to interpret; it often erroneously appears fibrous in origin and may be considered to be benign. Despite this benign appearance histologically, the tumor behaves aggressively with multiple local recurrences and possible CNS invasion by either direct perineural growth or distant metastases. We review the literature of neurotropic melanomas and report a 46th case which describes a typical course with neural invasion. Although a rare cause of cranial neuropathies, the neurologist should consider this entity in the differential diagnosis and the history of a recurrent skin lesion of the face should be sought whenever examining such a patient. Kluwer Academic Publishers, 1992 melanoma nationallicence neurotropic nationallicence neurotropism nationallicence cranial neuropathy nationallicence Mack Ellen Department of Neurology, Cornell University Medical Center and Memorial Sloan-Kettering Cancer Center, New York, NY aut Gomez Edward Department of Dermatology, UC, Davis School of Medicine, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 165-171 0167-594X 13:2<165 1992 13 11060 https://doi.org/10.1007/BF00172766 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00172766 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mack Ellen Department of Neurology, Cornell University Medical Center and Memorial Sloan-Kettering Cancer Center, New York, NY aut NATIONALLICENCE 700 1- Gomez Edward Department of Dermatology, UC, Davis School of Medicine, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 13/2(1992-06-01), 165-171 0167-594X 13:2<165 1992 13 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer